Evidence map›Paper›PMID 39177793›Full record

ArticleAnnals of hematology2024

Approaches for the diagnosis and treatment of VEXAS syndrome: the importance of clinical suspicion and the use of methotrexate.

Maria De Santis, Antonio Tonutti, Francesca Motta, Gabriele Todisco, Nicla Manes, Chiara Milanesi, Rossella Caselli, Serena Albertazzi, Arturo Bonometti, Carlo Selmi and 1 more

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In one paragraph

Article in Annals of hematology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Maria De SantisDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.
Antonio TonuttiDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.
Francesca MottaDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.
Gabriele TodiscoDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.
Nicla ManesDepartment of Oncology and Hematology, Humanitas Cancer Center, IRCCS Humanitas Research Hospital, Rozzano, Italy.
Chiara MilanesiDepartment of Oncology and Hematology, Humanitas Cancer Center, IRCCS Humanitas Research Hospital, Rozzano, Italy.
Rossella CaselliDepartment of Oncology and Hematology, Humanitas Cancer Center, IRCCS Humanitas Research Hospital, Rozzano, Italy.
Serena AlbertazziDepartment of Oncology and Hematology, Humanitas Cancer Center, IRCCS Humanitas Research Hospital, Rozzano, Italy.
Arturo BonomettiDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.
Carlo SelmiDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy. antonio.tonutti@humanitas.it.
Matteo Giovanni Della PortaDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vacuoles, E1-enzyme, X-linked, Autoinflammatory, Somatic (VEXAS) syndrome is caused by mutations in the UBA1 gene in myeloid precursors, leading to systemic inflammatory manifestations. We present the case of a 75-year-old man presenting with fever, panniculitis, and macrocytic anemia testing repeatedly negative for UBA1 mutations in peripheral blood samples, but ultimately found positive on bone marrow mononuclear cell DNA. The man has been successfully treated with prednisone and methotrexate.

Indexed as

Genetic Diseases, X-LinkedHereditary Autoinflammatory DiseasesMethotrexateUbiquitin-Activating EnzymesAgedAnemia, MacrocyticHumansMaleMutationPanniculitisPrednisoneSyndromeMethotrexatePrednisoneUBA1 protein, humanUbiquitin-Activating EnzymesAgeingAutoinflammatory syndromeBone marrowImmunologySanger sequencing

Identifiers

PMID39177793

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.