Evidence map›Paper›PMID 39177752›Full record

ArticleCalcified tissue international2024

Deficiency of Trps1 in Cementoblasts Impairs Cementogenesis and Tooth Root Formation.

Kaoru Fujikawa, Mairobys Socorro, Lyudmila Lukashova, Priyanka Hoskere, Paulina Keskinidis, Kostas Verdelis, Dobrawa Napierala

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Calcified tissue international, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Pathogenesis and potential therapeutic targets of trichorhinophalangeal syndrome; lessons obtained from animal studies.Developmental dynamics : an official publication of the American Association of Anatomists · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kaoru FujikawaCenter for Craniofacial Regeneration, Department of Oral and Craniofacial Sciences, School of Dental Medicine, University of Pittsburgh, 501 Salk Pavilion, 335 Sutherland Drive, Pittsburgh, PA, 15213, USA.
Mairobys SocorroCenter for Craniofacial Regeneration, Department of Oral and Craniofacial Sciences, School of Dental Medicine, University of Pittsburgh, 501 Salk Pavilion, 335 Sutherland Drive, Pittsburgh, PA, 15213, USA.
Lyudmila LukashovaCenter for Craniofacial Regeneration, Department of Oral and Craniofacial Sciences, School of Dental Medicine, University of Pittsburgh, 501 Salk Pavilion, 335 Sutherland Drive, Pittsburgh, PA, 15213, USA.
Priyanka HoskereCenter for Craniofacial Regeneration, Department of Oral and Craniofacial Sciences, School of Dental Medicine, University of Pittsburgh, 501 Salk Pavilion, 335 Sutherland Drive, Pittsburgh, PA, 15213, USA.
Paulina KeskinidisCenter for Craniofacial Regeneration, Department of Oral and Craniofacial Sciences, School of Dental Medicine, University of Pittsburgh, 501 Salk Pavilion, 335 Sutherland Drive, Pittsburgh, PA, 15213, USA.
Kostas VerdelisCenter for Craniofacial Regeneration, Department of Endodontics, School of Dental Medicine, University of Pittsburgh, 501 Salk Pavilion, 335 Sutherland Drive, Pittsburgh, PA, 15213, USA.
Dobrawa NapieralaCenter for Craniofacial Regeneration, Department of Oral and Craniofacial Sciences, School of Dental Medicine, University of Pittsburgh, 501 Salk Pavilion, 335 Sutherland Drive, Pittsburgh, PA, 15213, USA. don11@pitt.edu.ORCID 0000-0002-7383-1011

Funding

Transcriptional Regulation of Dentin MineralizationR01DE023083 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NAPIERALA, DOBRAWA · 2014 to 2018
$1.9M
Phosphate signaling in biomineralizationR01AR074981 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NAPIERALA, DOBRAWA · 2019 to 2023
$1.7M
Role of Mineralization-Regulating Transcription Factors in Susceptibility to Dental CariesF32DE029096 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SOCORRO, MAIROBYS · 2020 to 2022
$223k
NIAMS NIH HHS AR074981NIAMS NIH HHS R01 AR074981NIDCR NIH HHS DE023083NIDCR NIH HHS F32 DE029096NIDCR NIH HHS F32DE029096NIDCR NIH HHS R01 DE023083
6 · The paper itself

Abstract

Cementum is the least studied of all mineralized tissues and little is known about mechanisms regulating its formation. Therefore, the goal of this study was to provide new insights into the transcriptional regulation of cementum formation by determining the consequences of the deficiency of the Trps1 transcription factor in cementoblasts. We used Trps1

Indexed as

Dental CementumRepressor ProteinsTooth RootTranscription FactorsAnimalsCementogenesisDNA-Binding ProteinsFemaleMaleMiceMice, KnockoutX-Ray MicrotomographyDNA-Binding ProteinsRepressor ProteinsTranscription FactorsTrps1 protein, mouseCementoblastCementumConditional knockout micePeriodontiumTooth rootTRPS1

Identifiers

PMID39177752
PMCPMC11531424

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.