Evidence map›Paper›PMID 39177734›Full record

ArticleMolecular neurobiology2025

Specific Activation of Dopamine Receptor D1 Expressing Neurons in the PrL Alleviates CSDS-Induced Anxiety-Like Behavior Comorbidity with Postoperative Hyperalgesia in Male Mice.

Wang Wang, Weizhen Liu, Sufang Liu, Dongxiao Duan, Yajing Ma, Zijuan Zhang, Changsheng Li, Yuanyuan Tang, Zhiju Wang, Ying Xing

Abstract read
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In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Wang WangDepartment of Physiology and Neurobiology, School of Basic Medical Sciences, Zhengzhou University, No.100 Science Road, Gao-Xin District, Henan, 450001, Zhengzhou, China.
Weizhen LiuDepartment of Physiology and Neurobiology, School of Basic Medical Sciences, Zhengzhou University, No.100 Science Road, Gao-Xin District, Henan, 450001, Zhengzhou, China.
Sufang LiuDepartment of Biomedical Sciences, Texas A&M University College of Dentistry, Dallas, TX75246, USA.
Dongxiao DuanDepartment of Physiology and Neurobiology, School of Basic Medical Sciences, Zhengzhou University, No.100 Science Road, Gao-Xin District, Henan, 450001, Zhengzhou, China.
Yajing MaCollege of Biology and Food, Shangqiu Normal University, Shangqiu, 476000, China.
Zijuan ZhangSchool of Basic Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, 450046, China.
Changsheng LiDepartment of Anesthesiology, the Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Yuanyuan TangSchool of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, 453003, China.
Zhiju WangDepartment of Physiology and Neurobiology, School of Basic Medical Sciences, Zhengzhou University, No.100 Science Road, Gao-Xin District, Henan, 450001, Zhengzhou, China. zhijuwang@zzu.edu.cn.
Ying XingDepartment of Physiology and Neurobiology, School of Basic Medical Sciences, Zhengzhou University, No.100 Science Road, Gao-Xin District, Henan, 450001, Zhengzhou, China. xingy@zzu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Postoperative pain is a type of pain that occurs in clinical patients after surgery. Among the factors influencing the transition from acute postoperative pain to chronic postoperative pain, chronic stress has received much attention in recent years. Here, we investigated the role of dopamine receptor D1/D2 expressing pyramidal neurons in the prelimbic cortex (PrL) in modulating chronic social defeat stress (CSDS)-induced anxiety-like behavior comorbidity with postoperative hyperalgesia in male mice. Our results showed that preoperative CSDS induced anxiety-like behavior and significantly prolonged postoperative pain caused by plantar incision, but did not affect plantar wound recovery and inflammation. Reduced activation of dopamine receptor D1 or D2 expressing neurons in the PrL is a remarkable feature of male mice after CSDS, and chronic inhibition of dopamine receptor D1 or D2 expressing neurons in the PrL induced anxiety-like behavior and persistent postoperative pain. Further studies found that activation of D1 expressing but not D2 expressing neurons in the PrL ameliorated CSDS-induced anxiety-like behavior and postoperative hyperalgesia. Our results suggest that dopamine receptor D1 expressing neurons in the PrL play a crucial role in CSDS-induced anxiety-like behavior comorbidity with postoperative hyperalgesia in male mice.

Indexed as

AnxietyHyperalgesiaNeuronsPostoperative PainPrefrontal CortexReceptors, Dopamine D1Social DefeatStress, PsychologicalAnimalsBehavior, AnimalComorbidityMaleMiceMice, Inbred C57BLPyramidal CellsReceptors, Dopamine D2Receptors, Dopamine D1Receptors, Dopamine D2Anxiety-like behaviorChronic social defeat stressDopamine receptorPostoperative hyperalgesiaPrelimbic cortex

Identifiers

PMID39177734

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.