Evidence map›Paper›PMID 39177727›Full record

ArticleJournal of computer-aided molecular design2024

Computational design and experimental confirmation of a disulfide-stapled YAP helix

Kaipeng Li, Lijun Liu

Abstract read
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In one paragraph

Article in Journal of computer-aided molecular design, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Kaipeng LiSchool of Chemistry and Chemical Engineering, Jinggangshan University, No. 28, Xueyuan Road, Ji'an, 343009, China.
Lijun LiuSchool of Chemistry and Chemical Engineering, Jinggangshan University, No. 28, Xueyuan Road, Ji'an, 343009, China. lij_liu@163.com.ORCID 0000-0002-5440-9595

Funding

Jiangxi Provincial Natural Science Foundation 20202BABL206111Jinggangshan University Startup Fund for Doctor Research JZB11035Natural Science Foundation of Jiangxi Province 20202BABL206111
6 · The paper itself

Abstract

Human Hippo signaling pathway is an evolutionarily conserved regulator network that controls organ development and has been implicated in various cancers. Transcriptional enhanced associate domain-4 (TEAD4) is the final nuclear effector of Hippo pathway, which is activated by Yes-associated protein (YAP) through binding to two separated YAP regions of α1-helix and Ω-loop. Previous efforts have all been addressed on deriving peptide inhibitors from the YAP to target TEAD4. Instead, we herein attempted to rationally design a so-called 'YAP helix

Indexed as

Adaptor Proteins, Signal TransducingAntineoplastic AgentsDNA-Binding ProteinsMolecular Dynamics SimulationMuscle ProteinsTEA Domain Transcription FactorsTranscription FactorsYAP-Signaling ProteinsBinding SitesCell Line, TumorComputer-Aided DesignDisulfidesDrug DesignHumansProtein BindingAdaptor Proteins, Signal TransducingAntineoplastic AgentsDisulfidesDNA-Binding ProteinsMuscle ProteinsTEAD4 protein, humanTEA Domain Transcription FactorsTranscription FactorsYAP1 protein, humanYAP-Signaling ProteinsDisulfide staplingHippo signaling pathwayRational molecular designTranscriptional enhanced associate domain-4YAP helixα1-trapYes-associated protein

Identifiers

PMID39177727

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.