Dual feedback inhibition of ATP-dependent caffeate activation economizes ATP in caffeate-dependent electron bifurcation.

Fengjun Xu, Calvin J Thoma, Weiyang Zhao, Yiwen Zhu, Yujie Men, Lawrence P Wackett

Abstract read

In one paragraph

Article in Applied and environmental microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Fengjun XuDepartment of Chemical and Environmental Engineering, University of California, Riverside, California, USA.ORCID 0000-0002-6627-2610

Calvin J ThomaDepartment of Biochemistry, Molecular Biology & Biophysics, BioTechnology Institute, University of Minnesota, St. Paul, Minnesota, USA.

Weiyang ZhaoDepartment of Chemical and Environmental Engineering, University of California, Riverside, California, USA.

Yiwen ZhuDepartment of Chemical and Environmental Engineering, University of California, Riverside, California, USA.

Yujie MenDepartment of Chemical and Environmental Engineering, University of California, Riverside, California, USA.ORCID 0000-0001-9811-3828

Lawrence P WackettDepartment of Biochemistry, Molecular Biology & Biophysics, BioTechnology Institute, University of Minnesota, St. Paul, Minnesota, USA.ORCID 0000-0002-3255-1101

Funding

Minnesota's Discovery, Research, and Innovation EconomyOASIS Internal Funding Award at University of California Riverside

6 · The paper itself

Abstract

The acetogen IMPORTANCE: This study reports a dual feedback inhibition of caffeoyl-CoA synthetase by two downstream products, hydrocaffeate and hydrocaffeoyl-CoA. It elucidates how such dual feedback inhibition suppresses ATP-dependent caffeoyl-CoA synthesis, hence making the ATP-independent route the main pathway of caffeate activation. This newly discovered mechanism contributes to our current understanding of ATP conservation during the caffeate-dependent electron-bifurcating pathway in the ecologically important acetogen

Indexed as

AcetobacteriumAdenosine TriphosphateCaffeic AcidsBacterial ProteinsCoenzyme A LigasesElectron TransportFeedback, PhysiologicalOxidation-ReductionAdenosine TriphosphateBacterial Proteinscaffeic acidCaffeic AcidsCoenzyme A LigasesAcetobacterium woodiiacetogencaffeate reductionCarACarBenergy conservationfeedback inhibitionflavin-based electron bifurcation

Identifiers

PMID39177329

DOI10.1128/aem.00602-24

PMCPMC11409703

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.