Evidence map›Paper›PMID 39177283›Full record

ArticleVeterinary medicine and science2024

A case report of feline mast cell tumour with intertumoral heterogeneity: Identification of secondary mutations c.998G>C and c.2383G>C in KIT after resistance to toceranib.

Hiroyuki Tani, Tatsuro Hifumi, Keita Ito, Tomohide Kuramoto, Noriaki Miyoshi, Makoto Fujiki, Tomohiro Nakayama

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary medicine and science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hiroyuki TaniLaboratory of Veterinary Radiology, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa, Japan.ORCID 0000-0002-5035-913X
Tatsuro HifumiLaboratory of Veterinary Histopathology, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan.ORCID 0009-0006-7511-0767
Keita ItoCanine-Lab. Inc., Koganei, Tokyo, Japan.
Tomohide KuramotoKagoshima University Veterinary Teaching Hospital, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan.
Noriaki MiyoshiLaboratory of Veterinary Histopathology, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan.
Makoto FujikiKagoshima University Veterinary Teaching Hospital, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan.
Tomohiro NakayamaLaboratory of Veterinary Radiology, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa, Japan.

Funding

Grant-in-Aid for Scientific Research JP21K14991Japan Society for the Promotion of Science
6 · The paper itself

Abstract

A 12-year-old male domestic cat with multiple subcutaneous mast cell tumours (MCTs) presented with a 2-week history of pruritus and raw/bleeding skin from self-trauma at Kagoshima University Veterinary Teaching Hospital. Polymerase chain reaction (PCR) and histopathological analyses revealed intertumoral heterogeneity among tumour locations based on the mutation status of KIT. In addition, the expression pattern of KIT was characterized. After failed treatment with vinblastine (2.0-2.2 mg/m

Indexed as

Cat DiseasesDrug Resistance, NeoplasmIndolesMutationProto-Oncogene Proteins c-kitPyrrolesAnimalsAntineoplastic AgentsCatsMaleAntineoplastic AgentsIndolesProto-Oncogene Proteins c-kitPyrrolestoceranib phosphateacquired resistancecatheterogeneityKIT mutationmast cell tumourresistance to toceranib

Identifiers

PMID39177283
PMCPMC11342349

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.