Evidence map›Paper›PMID 39177233›Full record

ArticleJournal of magnetic resonance imaging : JMRI2025

Associations Between Brain Metabolites Measured With MR Spectroscopy and Head Impacts in High School American Football Athletes.

Zexuan Liu, Jonathan A Dudley, Jed A Diekfuss, Nadine Ahmed, Alex D Edmondson, Kim M Cecil, Weihong Yuan, Taylor M Zuleger, Alexis B Slutsky-Ganesh, Kim D Barber Foss and 2 more

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In one paragraph

Article in Journal of magnetic resonance imaging : JMRI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zexuan LiuDepartment of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0001-7463-1612
Jonathan A DudleyImaging Research Center, Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Jed A DiekfussEmory Sports Performance and Research Center (SPARC), Flowery Branch, Georgia, USA.
Nadine AhmedDepartment of Neuroscience, Georgia Institute of Technology, Atlanta, Georgia, USA.
Alex D EdmondsonImaging Research Center, Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Kim M CecilImaging Research Center, Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Weihong YuanImaging Research Center, Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Taylor M ZulegerEmory Sports Performance and Research Center (SPARC), Flowery Branch, Georgia, USA.
Alexis B Slutsky-GaneshEmory Sports Performance and Research Center (SPARC), Flowery Branch, Georgia, USA.
Kim D Barber FossEmory Sports Performance and Research Center (SPARC), Flowery Branch, Georgia, USA.
Gregory D MyerDepartment of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA.
Candace C FleischerDepartment of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0003-3265-2276

Funding

A novel framework for quantifying metabolic brain healthDP2NS127704 · NINDS · EMORY UNIVERSITY · PI FLEISCHER, CANDACE C. · 2021 to 2024
$2.3M
NINDS NIH HHS DP2 NS127704
6 · The paper itself

Abstract

backgroundWhile changes in brain metabolites after injury have been reported, relationships between metabolite changes and head impacts are less characterized. PURPOSE: To investigate alterations in neurochemistry in high school athletes as a function of head impacts, concussion, and the use of a jugular vein compression (JVC) collar. STUDY TYPE: Prospective controlled trial. SUBJECTS: A total of 284 male American football players, divided into JVC collar and noncollar groups; 215 included in final analysis (age = 15.9 ± 1.0 years; 114 in collar group). FIELD STRENGTH/SEQUENCE: 3 Tesla/T ASSESSMENT: Head impacts were quantified using accelerometers. Concussion was diagnosed by medical professionals for each team. Pre- to postseason differences in total N-acetylaspartate (tNAA), total choline (tCho), myo-inositol (myoI), and glutamate + glutamine (Glx), in primary motor cortex (M1) and anterior cingulate cortex (ACC), relative to total creatine (tCr), were determined. STATISTICAL TESTS: Group-wise comparisons were performed using Wilcoxon signed-rank, Friedman's, and Mann-Whitney U tests. Relationships between ∆metabolite/tCr and mean g-force were analyzed using linear regressions accounting for concussion and JVC collar. Significance was set at P ≤ 0.05.

resultsIn participants without concussion, a significant decrease in tCho/tCr (0.233 ± 1.40 × 10 DATA

conclusionDiagnosed concussion and the use of a JVC collar result in distinct neurochemical trends after repeated head impacts. LEVEL OF EVIDENCE: 2 TECHNICAL EFFICACY: Stage 3.

Indexed as

BrainBrain ConcussionFootballAdolescentAspartic AcidAthletesAthletic InjuriesCholineCreatineGlutamic AcidGlutamineHumansInositolMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMaleAspartic AcidCholineCreatineGlutamic AcidGlutamineInositolN-acetylaspartateAmerican footballconcussionMR spectroscopytraumatic brain injury

Identifiers

PMID39177233
PMCPMC11896922

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.