Evidence map›Paper›PMID 39177026›Full record

ArticleJournal of peptide science : an official publication of the European Peptide Society2025

Rational design of self-assembling ultrashort peptides for the shape- and size-tunable synthesis of metal nanostructures.

Urawadee Rajchakit, Hugh Douglas Glossop, Kelvin Wang, Jun Lu, Vijayalekshmi Sarojini

Abstract read
In one paragraph

Article in Journal of peptide science : an official publication of the European Peptide Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Gold Nanoparticles Guided by Self-Assembling Peptides: From Sequence to Superstructure.Chembiochem : a European journal of chemical biology · 2025
    Review
  3. Rational design of self-assembling ultrashort peptides for the shape- and size-tunable synthesis of metal nanostructures.Journal of peptide science : an official publication of the European Peptide Society · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Urawadee RajchakitSchool of Chemical Sciences and The Centre for Green Chemical Science, University of Auckland, Auckland, New Zealand.ORCID https://orcid.org/0000-0002-8410-192X
Hugh Douglas GlossopSchool of Chemical Sciences and The Centre for Green Chemical Science, University of Auckland, Auckland, New Zealand.ORCID https://orcid.org/0000-0001-8543-4569
Kelvin WangAuckland Bioengineering Institute, University of Auckland, Auckland, New Zealand.
Jun LuAuckland Bioengineering Institute, University of Auckland, Auckland, New Zealand.ORCID https://orcid.org/0000-0003-0225-6643
Vijayalekshmi SarojiniSchool of Chemical Sciences and The Centre for Green Chemical Science, University of Auckland, Auckland, New Zealand.ORCID https://orcid.org/0000-0002-5593-8851

Funding

University of Auckland Doctoral Scholarship
6 · The paper itself

Abstract

Peptides have attracted great interest as platforms for the design of nanocomposite hydrogels due to their distinct bioactivity, biofunctionality and biocompatibility. Previously, we have reported on a family of peptides that self-assembled to form stabilised three-dimensional hydrogel networks, displaying potent antimicrobial activity. In this paper, we report on the use of these hydrogelator sequences and their analogues as stabilisers and growth controllers to synthesise anisotropic gold nanoparticles (AuNPs) of different sizes and shapes. In particular, hollow spherical nanoparticles were obtained for HG2.81-AuNPs, whereas hexagonal nanoparticles were observed for TOH_1N-AuNPs and PentaOH-AuNPs in their respective hydrogel networks. The PentaOH-AuNPs' hydrogel exhibited excellent results with high antimicrobial potency against Staphylococcus aureus and Pseudomonas aeruginosa ATCC 27853 and negligible cytotoxicity. On the other hand, TOH_1N-AuNPs showed no antibacterial activity and no cytotoxicity, demonstrating the versatility of these peptides. This work gives credence towards the development of these materials towards further applications such as in tissue culture technology and wound dressing materials.

Indexed as

Anti-Bacterial AgentsGoldHydrogelsMetal NanoparticlesMicrobial Sensitivity TestsParticle SizePeptidesPseudomonas aeruginosaStaphylococcus aureusHumansAnti-Bacterial AgentsGoldHydrogelsPeptidesantimicrobial activitygold nanoparticleshydrogelpeptidesize‐controlled synthesis

Identifiers

PMID39177026
PMCPMC11602218

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.