Evidence map›Paper›PMID 39176982›Full record

SynthesisJournal of cosmetic dermatology2024

"Effectiveness of minimally invasive injectable modalities in the management of androgenetic alopecia among adults-A systematic review".

Vaibhav Kumar, Michael Gold, Anuj Jain, Pranjal Mhatre, Ungku Mohd Shahrin B Mohd Zaman, Rinky Kapoor, Debraj Shome

Abstract readSystematic Review
In one paragraph

Synthesis in Journal of cosmetic dermatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Vaibhav KumarDepartment of Research, The Esthetic Clinics, Mumbai, Maharashtra, India.ORCID https://orcid.org/0000-0003-2166-1740
Michael GoldGold Skin Care Center, Tennessee Clinical Research Center, Nashville, Tennessee, USA.ORCID https://orcid.org/0000-0002-5183-5433
Anuj JainDepartment of Oral and Maxillofacial Surgery, Dr. Hedgewar Smruti Rugna Seva Mandal's Dental College and Hospital, Hingoli, Maharashtra, India.ORCID https://orcid.org/0000-0002-0036-9663
Pranjal MhatreDepartment of Research, The Esthetic Clinics, Mumbai, Maharashtra, India.
Ungku Mohd Shahrin B Mohd ZamanMedicine, Bioscience and Nursing Faculty, MAHSA University, Kuala Lumpur, Malaysia.
Rinky KapoorDepartment of Dermatology, Cosmetic Dermatology and Dermatosurgery, The Esthetic Clinics, Mumbai, Maharashtra, India.
Debraj ShomeDepartment of Facial Plastic Surgery and Facial Cosmetic Surgery, The Esthetic Clinics, Mumbai, Maharashtra, India.ORCID https://orcid.org/0000-0003-2163-1170

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAndrogenetic alopecia is the most common cause of hair loss that affects over 50% of the world population. It is a condition that is multifactorial in origin, with no specific causative factor, making treatment an enervating experience for the patient as well as the doctor. In recent times, a number of modalities have been introduced for the treatment of alopecia. However, the evidence supporting them is unstructured and sparse. Therefore, this article aims to explore the current trends in minimally invasive treatments for the management of androgenetic alopecia.

methodsAn in-depth literature search on injectables used in the treatment of alopecia in PubMed/MEDLINE, Embase, PsycINFO, TRIP Cochrane Library, and Cochrane Skin databases between January 2000 and May 2023 was performed. The studies included were randomized controlled trials, non-randomized trials, quasi trials, single arm interventions, and cohort studies.

resultsSixteen of the 1071 studies that were found during the original search were accepted in accordance with the inclusion criteria. Twelve studies assessed the effectiveness of the injectable group by comparing it to a control group consisting of saline, distilled water, and topical minoxidil. In the treatment of alopecia, dutasteride and injectable growth factor formulations achieved clinically significant results.

conclusionThe usage of injectables and topical medicines to treat hair loss has increased in the recent years. Overall results from clinical investigations, pilot studies, and trials looking at the efficacy and safety of these growth factors in the AGA show satisfactory efficacy.

Indexed as

AlopeciaMinoxidilAdultDutasterideHairHumansInjectionsTreatment OutcomeDutasterideMinoxidilandrogenetic alopeciabiomimetic polypeptidesgrowth factorshair regrowth treatmentsminimally invasive therapiesQR678

Identifiers

PMID39176982
PMCPMC13649107

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.