Evidence map›Paper›PMID 39176228›Full record

ArticleFrontiers in psychiatry2024

Altered dynamic neural activities in individuals with obsessive-compulsive disorder and comorbid depressive symptoms.

Tinghuizi Shang, Yunhui Chen, Zhenning Ding, Weiqi Qin, Shancong Li, Siyi Wei, Zhipeng Ding, Xu Yang, Jiale Qi, Xiaoqing Qin and 10 more

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Article in Frontiers in psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

20 authors.

Tinghuizi Shang *Department of Psychiatry, Qiqihar Medical University, Qiqihar, Heilongjiang, China.
Yunhui Chen *Department of Psychiatry, Qiqihar Medical University, Qiqihar, Heilongjiang, China.
Zhenning DingMedical Imaging Department, Qingdao Mental Health Center, Qingdao, Shandong, China.
Weiqi QinThe Second Affiliated Hospital, Qiqihar Medical University, Qiqihar, Heilongjiang, China.
Shancong LiThe Second Affiliated Hospital, Qiqihar Medical University, Qiqihar, Heilongjiang, China.
Siyi WeiDepartment of Psychiatry, Qiqihar Medical University, Qiqihar, Heilongjiang, China.
Zhipeng DingMedical Technology Department, Qiqihar Medical University, Qiqihar, Heilongjiang, China.
Xu YangMedical Technology Department, Qiqihar Medical University, Qiqihar, Heilongjiang, China.
Jiale QiMedical Technology Department, Qiqihar Medical University, Qiqihar, Heilongjiang, China.
Xiaoqing QinMedical Technology Department, Qiqihar Medical University, Qiqihar, Heilongjiang, China.
Dan LvDepartment of Psychiatry, Qiqihar Medical University, Qiqihar, Heilongjiang, China.
Tong LiDepartment of Psychiatry, Qiqihar Medical University, Qiqihar, Heilongjiang, China.
Zan PanInfection Control Department, Harbin Puning Hospital, Harbin, Heilongjiang, China.
Chuang ZhanDepartment of Psychiatry, Baiyupao Psychiatric Hospital of Harbin, Harbin, Heilongjiang, China.
Jian XiaoDepartment of Psychiatry, Qiqihar Medical University, Qiqihar, Heilongjiang, China.
Zhenghai SunDepartment of Psychiatry, Qiqihar Medical University, Qiqihar, Heilongjiang, China.
Na WangDepartment of Psychiatry, Qiqihar Medical University, Qiqihar, Heilongjiang, China.
Zengyan YuDepartment of Psychiatry, Qiqihar Medical University, Qiqihar, Heilongjiang, China.
Chengchong LiDepartment of Psychiatry, Qiqihar Medical University, Qiqihar, Heilongjiang, China.
Ping LiDepartment of Psychiatry, Qiqihar Medical University, Qiqihar, Heilongjiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Depressive symptoms are the most prevalent comorbidity in individuals with obsessive-compulsive disorder (OCD). The objective of this study was to investigate the dynamic characteristics of resting-state neural activities in OCD patients with depressive symptoms. Methods: We recruited 29 OCD patients with depressive symptoms, 21 OCD patients without depressive symptoms, and 27 healthy controls, and collected data via structural and functional magnetic resonance imaging (fMRI). We analyzed the fMRI results using the dynamic amplitude of low-frequency fluctuation (dALFF) and support vector machine (SVM) techniques. Results: Compared with OCD patients without depressive symptoms, OCD patients with depressive symptoms exhibited an increased dALFF in the left precuneus and decreased dALFF in the right medial frontal gyrus. The SVM indicated that the integration of aberrant dALFF values in the left precuneus and right medial frontal gyrus led to an overall accuracy of 80%, a sensitivity of 79%, and a specificity of 100% in detecting depressive symptoms among OCD patients. Conclusion: Therefore, our study reveals that OCD patients with depressive symptoms display neural activities with unique dynamic characteristics in the resting state. Accordingly, abnormal dALFF values in the left precuneus and right medial frontal gyrus could be used to identify depressive symptoms in OCD patients.

Indexed as

depressive symptomsdynamic amplitude of low frequency fluctuationmagnetic resonance imagingobsessive-compulsive disorderresting state

Identifiers

PMID39176228
PMCPMC11339690

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