Evidence map›Paper›PMID 39176091›Full record

ArticleFrontiers in immunology2024

Potentially functional variants of

Guojun Lu, Hongliang Liu, Huilin Wang, Xiaozhun Tang, Sheng Luo, Mulong Du, David C Christiani, Qingyi Wei

Abstract read
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Guojun LuDepartment of Respiratory Medicine, Nanjing Chest Hospital, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China.
Hongliang LiuDuke Cancer Institute, Duke University Medical Center, Durham, NC, United States.
Huilin WangDuke Cancer Institute, Duke University Medical Center, Durham, NC, United States.
Xiaozhun TangDuke Cancer Institute, Duke University Medical Center, Durham, NC, United States.
Sheng LuoDepartment of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC, United States.
Mulong DuDepartments of Environmental Health and Epidemiology, Harvard TH Chan School of Public Health, Boston, MA, United States.
David C ChristianiDepartments of Environmental Health and Epidemiology, Harvard TH Chan School of Public Health, Boston, MA, United States.
Qingyi WeiDuke Cancer Institute, Duke University Medical Center, Durham, NC, United States.

Funding

Women's Cancer Research ProgramP30CA014236 · NCI · DUKE UNIVERSITY · PI Laura Fish · 1985 to 2026
$174.8M
The Boston Lung Cancer Survival CohortU01CA209414 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI David C Christiani · 2017 to 2026
$12.2M
Translational studies of Hsp90 inhibitors in NSCLCP50CA090578 · NCI · DANA-FARBER CANCER INST · PI MEYERSON, MATTHEW L. · 2008 to 2012
$11.4M
Statistical Methods for Analysis of Massive Genetic and Genomic Data in Cancer ResearchR35CA197449 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI XIHONG LIN · 2015 to 2026
$10.9M
Molecular Epidemiology of Head and Neck CancerR01ES011740 · NIEHS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI WEI, QINGYI · 2001 to 2012
$6.3M
Molecular and Genetic Analysis of Lung Cancer SurvivalR01CA092824 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI CHRISTIANI, DAVID C · 2002 to 2013
$5.9M
SPORE in Lung CancerP20CA090578 · NCI · DANA-FARBER CANCER INSTITUTE · PI JOHNSON, BRUCE E. · 2003 to 2007
$5.1M
GENETIC SUSCEPTIBILITY TO LUNG CANCERR01CA074386 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI CHRISTIANI, DAVID C · 1997 to 2008
$4.8M
Genotypes and Phenotypes of Apoptosis and Risk of Head and Neck CancerR01CA131274 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI WEI, QINGYI · 2009 to 2013
$3.0M
NCI NIH HHS P20 CA090578NCI NIH HHS P30 CA014236NCI NIH HHS P50 CA090578NCI NIH HHS R01 CA074386NCI NIH HHS R01 CA092824NCI NIH HHS R01 CA131274NCI NIH HHS R35 CA197449NCI NIH HHS U01 CA209414NIEHS NIH HHS R01 ES011740
6 · The paper itself

Abstract

B cells are adaptive immune cells in the tumor microenvironment and play an important role in tumor development and metastasis. However, the roles of genetic variants of the immunity B cell-related genes in the survival of patients with non-small cell lung cancer (NSCLC) remain unknown. In the present study, we first evaluated associations between 10,776 single nucleotide polymorphisms (SNPs) in 220 immunity B cell-related genes and survival of NSCLC in a discovery dataset of 1,185 patients from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial. We found that 369 SNPs were significantly associated with overall survival (OS) of NSCLC in multivariable Cox proportional hazards regression analysis (

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsPolymorphism, Single NucleotideAgedB-LymphocytesExosome Multienzyme Ribonuclease ComplexFemaleGenetic Predisposition to DiseaseGenotypeHumansLinkage DisequilibriumMaleMiddle AgedPhosphatidylinositol-3,4,5-Trisphosphate 5-PhosphatasesPhosphoric Monoester HydrolasesPrognosisEXOSC3 protein, humanExosome Multienzyme Ribonuclease ComplexINPP5D protein, humanPhosphatidylinositol-3,4,5-Trisphosphate 5-PhosphatasesPhosphoric Monoester HydrolasesRNA-Binding Proteinsimmunity B cellnon-small cell lung canceroverall survivalsingle-nucleotide polymorphismtumor microenvironment

Identifiers

PMID39176091
PMCPMC11338758

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.