Evidence map›Paper›PMID 39176029›Full record

ArticleFrontiers in nutrition2024

Dietary advanced glycation end-products and their associations with body weight on a Mediterranean diet and low-fat vegan diet: a randomized, cross-over trial.

Hana Kahleova, Tatiana Znayenko-Miller, Giulianna Motoa, Emma Eng, Alex Prevost, Jaime Uribarri, Richard Holubkov, Neal D Barnard

Registry-linked trialAbstract read
In one paragraph

Article in Frontiers in nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03698955 (A Randomized, Cross-Over Trial on the Effects of a Low-Fat Vegan Diet Versus a Mediterranean Diet on Body Weight), which is not on this map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03698955 nacompletednot on this map

A Randomized, Cross-Over Trial on the Effects of a Low-Fat Vegan Diet Versus a Mediterranean Diet on Body Weight

TypeinterventionalSponsorPhysicians Committee for Responsible MedicineRan2018 to 2019Enrolled62ConditionsOverweight, Obesity, Insulin ResistanceArmsPlant-based diet, Mediterranean Diet
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hana KahleovaPhysicians Committee for Responsible Medicine, Washington, DC, United States.
Tatiana Znayenko-MillerPhysicians Committee for Responsible Medicine, Washington, DC, United States.
Giulianna MotoaPhysicians Committee for Responsible Medicine, Washington, DC, United States.
Emma EngPhysicians Committee for Responsible Medicine, Washington, DC, United States.
Alex PrevostPhysicians Committee for Responsible Medicine, Washington, DC, United States.
Jaime UribarriIcahn School of Medicine at Mount Sinai, New York, NY, United States.
Richard HolubkovSchool of Medicine, University of Utah, Salt Lake City, UT, United States.
Neal D BarnardPhysicians Committee for Responsible Medicine, Washington, DC, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Evidence suggests that changes in dietary advanced glycation end-products (AGEs) may influence body weight, but the effects of different dietary patterns remain to be explored.The aim of this study was to compare the effects of a Mediterranean and a low-fat vegan diet on dietary AGEs and test their association with body weight. Materials and methods: In this randomized cross-over trial, 62 overweight adults were assigned to a Mediterranean or a low-fat vegan diet for 16-week periods in random order, separated by a 4-week washout. Body weight was the primary outcome. Three-day diet records were analyzed using the Nutrition Data System for Research software and dietary AGEs were estimated, using an established database. Statistical approaches appropriate for crossover trials were implemented. Results: Dietary AGEs decreased by 73%, that is, by 9,413 kilounits AGE/day (95% -10,869 to -7,957); Conclusion: Dietary AGEs did not change on the Mediterranean diet but decreased on a low-fat vegan diet, and this decrease was associated with changes in body weight, independent of energy intake. Clinical trial registration: https://clinicaltrials.gov/, identifier NCT03698955.

Indexed as

advanced glycation end-productsdietMediterraneannutritionveganweight

Identifiers

PMID39176029
PMCPMC11340516

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.