Evidence map›Paper›PMID 39175990›Full record

ReviewTherapeutic advances in medical oncology2024

The influence of sex hormones on renal cell carcinoma.

Michael Ladurner, Andrea Katharina Lindner, Peter Rehder, Gennadi Tulchiner

Abstract readReview
In one paragraph

Review in Therapeutic advances in medical oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Michael LadurnerDepartment of Urology, Medical University of Innsbruck, Innsbruck, Austria.
Andrea Katharina LindnerDepartment of Urology, General Hospital Hall in Tirol, Hall in Tirol, Austria.
Peter RehderDepartment of Urology, Medical University of Innsbruck, Innsbruck, Austria.
Gennadi TulchinerDepartment of Urology, Medical University of Innsbruck, Anichstrasse 35, Innsbruck 6020, Austria.ORCID https://orcid.org/0000-0002-2964-1544

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Kidney cancer is a common malignancy that constitutes around 5% of all cancer cases. Males are twice as likely to acquire renal cell carcinoma (RCC) compared to females and experience a higher rate of mortality. These disparities indicate that sex hormone (SH)-dependent pathways may have an impact on the aetiology and pathophysiology of RCC. Examination of SH involvement in conventional signalling pathways, as well as genetics and genomics, especially the involvement of ribonucleic acid, reveal further insights into sex-related differences. An understanding of SHs and their influence on kidney cancer is essential to offer patients individualized medicine that would better meet their needs in terms of prevention, diagnosis and treatment. This review presents the understanding of sex-related differences in the clinical manifestation of kidney cancer patients and the underlying biological processes.

Indexed as

androgenhormone signalling axisimmune checkpoint inhibitorsoestrogenrenal cell carcinomaRNAsexsex hormonestumour microenvironment

Identifiers

PMID39175990
PMCPMC11339752

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.