Evidence map›Paper›PMID 39175985›Full record

ArticleOpen veterinary journal2024

Influence of azathioprine on healing of exposed dogs' dental pulp capped with three different materials.

Mokhtar A Al-Anesi, Ashraf M Abu-Seida, Ehab S Abd-Elhamid, Abeer H Mahran, Salma H El Ashry, Mohamed H Issa, Mohamed M Nagy

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Article in Open veterinary journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mokhtar A Al-AnesiDepartment of Endodontic, Faculty of Dentistry, Thamar University, Dhamar, Yemen.
Ashraf M Abu-SeidaDepartment of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.
Ehab S Abd-ElhamidFaculty of Dentistry, Ain Shams University, Cairo, Egypt.
Abeer H MahranFaculty of Dentistry, Ain Shams University, Cairo, Egypt.
Salma H El AshryFaculty of Dentistry, Ain Shams University, Cairo, Egypt.
Mohamed H IssaDepartment of Conservative Dentistry and Endodontics, Faculty of Dentistry, University of Tripoli, Tripoli, Libya.
Mohamed M NagyFaculty of Dentistry, Galala University, New Galala City, Suez, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Azathioprine is one of the earliest immunosuppressants prescribed for several autoimmune diseases. Yet there is a lack of research on the impact of azathioprine on pulp healing following the pulp capping procedure. Aim: This study aimed to investigate the effect of azathioprine on the healing ability of mechanically exposed dogs' dental pulps following direct pulp capping with mineral trioxide aggregate (MTA), bio-aggregates (BA), and Calcium hydroxide (Ca(OH) Methods: Four mongrel dogs were randomly assigned to two groups (two dogs/30 teeth in each group): immunosuppressed (group I) and control (group II). Group I received azathioprine for two months before surgical treatments and until the dogs were euthanized. Fifteen class V buccal cavities were performed in each dog. Each group was randomly divided into three subgroups (10 teeth each) based on the pulp capping substance. The pulps in subgroups A, B, and C were immediately capped with MTA, BA, and Ca(OH) Results: The immunosuppressed group exhibited statistically greater inflammatory cell count and decreased dentine bridge thickness, compared to the control group in all subgroups ( Conclusion: Azathioprine has an adverse effect on the healing of exposed dogs' dental pulp following direct pulp capping with MTA, BA, and Ca(OH)

Indexed as

AzathioprineCalcium CompoundsCalcium HydroxideDental Pulp CappingImmunosuppressive AgentsOxidesSilicatesAluminum CompoundsAnimalsDental PulpDog DiseasesDogsDrug CombinationsFemaleMalePulp Capping and Pulpectomy AgentsAluminum CompoundsAzathioprineCalcium CompoundsCalcium HydroxideDrug CombinationsImmunosuppressive Agentsmineral trioxide aggregateOxidesPulp Capping and Pulpectomy AgentsSilicatesBio-AggregatesCalcium hydroxideDentine bridgeImmunosuppressionMineral trioxide aggregate.

Identifiers

PMID39175985
PMCPMC11338621

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.