Evidence map›Paper›PMID 39175848›Full record

ArticleEuropean heart journal open2024

Efficacy of renal denervation as an adjunct to pulmonary vein isolation for atrial fibrillation treatment: a systematic review and meta-analysis.

Karish Thavabalan, Majed Sheikh, YuZhi Phuah, Sanjay K Rajput, Noor Fatima, Aman Sutaria, Jonathan J H Bray, Mahmood Ahmad, Hannah Glatzel, Reubeen Ahmad and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European heart journal open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Karish ThavabalanUniversity College London Medical School, 74 Huntley St, London WC1E 6DE, UK.ORCID https://orcid.org/0000-0001-7205-5076
Majed SheikhDepartment of Cardiology, Royal Free Hospital, London, UK.
YuZhi PhuahUniversity College London Medical School, 74 Huntley St, London WC1E 6DE, UK.
Sanjay K RajputUniversity College London Medical School, 74 Huntley St, London WC1E 6DE, UK.
Noor FatimaUniversity College London Medical School, 74 Huntley St, London WC1E 6DE, UK.
Aman SutariaUniversity College London Medical School, 74 Huntley St, London WC1E 6DE, UK.
Jonathan J H BrayUniversity College London Medical School, 74 Huntley St, London WC1E 6DE, UK.
Mahmood AhmadTahir Heart Institute, Rabwah, Pakistan.ORCID https://orcid.org/0000-0001-9107-3704
Hannah GlatzelStoke Mandeville Hospital, Aylesbury, UK.ORCID https://orcid.org/0000-0002-6253-0766
Reubeen AhmadBrighton and Sussex Medical School, Brighton, UK.
Lily SnellUniversity College London Medical School, 74 Huntley St, London WC1E 6DE, UK.
Niraj S KumarUniversity College London Medical School, 74 Huntley St, London WC1E 6DE, UK.
Carmen-Lucía García-PérezUniversity College London Medical School, 74 Huntley St, London WC1E 6DE, UK.
Luciano CandilioThe Hatter Cardiovascular Institute, University College London, London, UK.
Rui ProvidenciaInstitute of Health Informatics Research, 222 Euston Road, NW1 2DA London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: Catheter ablation, consisting of pulmonary vein isolation (PVI), is the most effective treatment modality for the management of symptomatic patients with atrial fibrillation (AF). Unfortunately, this procedure has a considerable relapse rate, ranging from 15 to 50% depending on AF type and other patient factors. Hypertension (HTN) is associated with a higher risk of developing AF and can also be managed with a catheter-based procedure-renal denervation (RDN). This meta-analysis aimed to compare the effect of PVI with and without RDN in hypertensive patients with AF. Methods and results: OVID MEDLINE and Embase were searched on 1 February 2023 and trials that reported the effects of RDN on AF recurrence in hypertensive patients were included. A total of 637 patients across 8 randomised controlled trials were included. The results from the pooled analysis showed that when compared with PVI alone, RDN added to PVI: (1) Lowered AF recurrence [RR 0.67 (0.53, 0.85), Conclusion: Adding RDN to PVI in patients with AF and resistant HTN was associated with a reduction of blood pressure levels and AF recurrence. Consideration to RDN should be given as an adjunctive treatment for patients with AF and resistant HTN.

Indexed as

Atrial fibrillationHypertensionRenal denervation

Identifiers

PMID39175848
PMCPMC11340072

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.