Evidence map›Paper›PMID 39175845›Full record

ArticleEuropean urology open science2024

Radical Prostatectomy in Kidney Transplant Recipients-A Multicenter Experience.

Jacob Schmidt, Abdulbaki Yakac, Robert Peters, Frank Friedersdorff, Karoline Kernig, Anna Kienel, Franziska I Winterhagen, Friedrich Köpp, Susan Foller, Francesca DiQuilio and 6 more

Abstract read
In one paragraph

Article in European urology open science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Jacob SchmidtDepartment of Urology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Abdulbaki YakacDepartment of Urology, University Hospital Carl Gustav Carus, Dresden, Germany.
Robert PetersDepartment of Urology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Frank FriedersdorffDepartment of Urology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Karoline KernigDepartment of Urology, University of Rostock, Rostock, Germany.
Anna KienelDepartment of Urology and Pediatric Urology, University Hospital Erlangen, Erlangen, Germany.
Franziska I WinterhagenDepartment of Urology, University Hospital Bonn, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany.
Friedrich KöppDepartment of Urology, Jena University Hospital, Jena, Germany.
Susan FollerDepartment of Urology, Jena University Hospital, Jena, Germany.
Francesca DiQuilioDepartment of Urology, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
Karl WeigandDepartment of Urology, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
Luka FlegarDepartment of Urology, Philipps-University Marburg, Marburg, Germany.
Philipp ReimoldDepartment of Urology, Philipps-University Marburg, Marburg, Germany.
Michael StöckleDepartment of Urology and Pediatric Urology, Saarland University, Homburg/Saar, Germany.
Juliane PutzDepartment of Urology, University Hospital Carl Gustav Carus, Dresden, Germany.
Philip ZeuschnerDepartment of Urology and Pediatric Urology, Saarland University, Homburg/Saar, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and objective: Kidney transplant recipients (KTRs) have an increased risk of developing genitourinary cancers, including prostate cancer (PCa), which is expected to become more prevalent due to an aging KTR population. Thus, knowledge of surgical outcomes, including treatment of PCa, within this unique cohort is required. Methods: Data of 62 KTRs undergoing radical prostatectomy (RP) between 2006 and 2023 at nine urologic transplant centers were analyzed. Complications were assessed using the Clavien-Dindo classification. Perioperative outcomes were evaluated, and a follow-up was conducted. Overall survival (OS), biochemical recurrence-free survival (BRFS), and death-censored graft survival were determined via the Kaplan-Meier method and log-rank testing. Key findings and limitations: Overall, 50 open radical retropubic RPs and 12 robot-assisted RPs (RARPs) were included. The intraoperative blood loss was lower after RARP, but operative time was longer. Of the patients, 50% experienced no postoperative complication, and grade ≥3 complications were observed in 14.5%. There was no graft loss related to RP. A histopathologic analysis revealed pN1 in 8.1% and positive surgical margins in 25.8% of the cases. At a median follow-up of 48.5 mo, the median OS was 128 (95% confidence interval [CI] 71.2-184.8) mo, BRFS was 106 (95% CI 55.8; 156.2) mo, and graft survival was 127 (95% CI 66.7-187.3) mo. Limitations include the retrospective design, and variations between groups and centers. Conclusions and clinical implications: Our findings support RP as a feasible and safe treatment option for localized PCa in KTRs with acceptable oncologic outcome. Special care is required in screening and awareness for the risk of understaging. Patient summary: This study analyzed the safety and effectiveness of two prostate cancer surgery methods-open and robot-assisted surgery-in the special group of kidney transplant recipients. Both surgical methods were performed safely with acceptable oncologic outcomes; however, sample size was too small to draw definite conclusions between the two operative methods.

Indexed as

Kidney transplantationOpen surgeryProstate cancerProstatectomyRobot-assisted surgery

Identifiers

PMID39175845
PMCPMC11339048

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.