Evidence map›Paper›PMID 39175800›Full record

ArticleEurophysics letters2023

A solution of the Crow-Kimura evolution model on fluctuating fitness landscape.

Vladimir Suvorov, David B SaAkian, Michael Lynch

Abstract read
In one paragraph

Article in Europhysics letters, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Vladimir SuvorovAuriga Inc. - 400 TradeCenter, Ste 5900 Woburn, MA 01801, USA.
David B SaAkianA.I. Alikhanyan National Science Laboratory (Yerevan Physics Institute) Foundation - 2 Alikhanian Brothers St., Yerevan 375036, Armenia.
Michael LynchBiodesign Center for Mechanisms of Evolution, Arizona State University - Tempe, AZ, 85287, USA.

Funding

Causes and Population-genetic Consequences of Molecular VariationR35GM122566 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI Michael R LYNCH · 2017 to 2026
$7.7M
NIGMS NIH HHS R35 GM122566
6 · The paper itself

Abstract

The article discusses the Crow-Kimura model in the context of random transitions between different fitness landscapes. The duration of epochs, during which the fitness landscape is constant over time, is modeled by an exponential distribution. To obtain an exact solution, a system of functional equations is required. However, to approximate the model, we consider the cases of slow or fast transitions and calculate the first-order corrections using either the transition rate or its inverse. Specifically, we focus on the case of slow transitions and find that the average fitness is equal to the average fitness for evolution on static fitness landscapes, but with the addition of a load term. We also investigate the model for a small number of genes and identify the exact transition points to the transient phase.

Identifiers

PMID39175800
PMCPMC11340687

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.