Evidence map›Paper›PMID 39175770›Full record

ArticleiScience2024

Glycogen synthase kinase 3 inhibition controls

Sandra Peña-Díaz, Joseph D Chao, Celine Rens, Hasti Haghdadi, Xingji Zheng, Keegan Flanagan, Mary Ko, Tirosh Shapira, Adrian Richter, Danay Maestre-Batlle and 5 more

Abstract read
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Sandra Peña-DíazDepartment of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada.
Joseph D ChaoDepartment of Medicine, University of British Columbia, Vancouver, BC, Canada.
Celine RensDepartment of Medicine, University of British Columbia, Vancouver, BC, Canada.
Hasti HaghdadiDepartment of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada.
Xingji ZhengDepartment of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada.
Keegan FlanaganDepartment of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada.
Mary KoDepartment of Medicine, University of British Columbia, Vancouver, BC, Canada.
Tirosh ShapiraDepartment of Medicine, University of British Columbia, Vancouver, BC, Canada.
Adrian RichterDepartment of Medicine, University of British Columbia, Vancouver, BC, Canada.
Danay Maestre-BatlleDepartment of Medicine, University of British Columbia, Vancouver, BC, Canada.
Julio Ortiz CansecoHost-pathogen Interactions in Tuberculosis Laboratory, The Francis Crick Institute, London, UK.
Maximiliano Gabriel GutierrezHost-pathogen Interactions in Tuberculosis Laboratory, The Francis Crick Institute, London, UK.
Khanh Dao DucDepartment of Mathematics, University of British Columbia, Vancouver, BC, Canada.
Steven PelechDepartment of Medicine, University of British Columbia, Vancouver, BC, Canada.
Yossef Av-GayDepartment of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Compounds targeting host control of infectious diseases provide an attractive alternative to antimicrobials. A phenotypic screen of a kinase library identified compounds targeting glycogen synthase kinase 3 as potent inhibitors of

Indexed as

Medical MicrobiologyMicrobiologyMolecular biology

Identifiers

PMID39175770
PMCPMC11340618

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.