Evidence map›Paper›PMID 39175753›Full record

ArticleFrontiers in genetics2024

GWAS-significant loci and severe COVID-19: analysis of associations, link with thromboinflammation syndrome, gene-gene, and gene-environmental interactions.

Alexey Valerevich Loktionov, Ksenia Andreevna Kobzeva, Andrey Romanovich Karpenko, Vera Alexeevna Sergeeva, Yuriy Lvovich Orlov, Olga Yurievna Bushueva

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In one paragraph

Article in Frontiers in genetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Special Issue "Bioinformatics of Gene Regulations and Structure-2025".International journal of molecular sciences · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Biomedicines · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alexey Valerevich LoktionovDepartment of Anesthesia and Critical Care, Institute of Continuing Education, Kursk State Medical University, Kursk, Russia.
Ksenia Andreevna KobzevaLaboratory of Genomic Research, Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, Kursk, Russia.
Andrey Romanovich KarpenkoDepartment of Anesthesia and Critical Care, Institute of Continuing Education, Kursk State Medical University, Kursk, Russia.
Vera Alexeevna SergeevaDepartment of Anesthesia and Critical Care, Institute of Continuing Education, Kursk State Medical University, Kursk, Russia.
Yuriy Lvovich OrlovInstitute of Biodesign and Complex Systems Modeling, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
Olga Yurievna BushuevaLaboratory of Genomic Research, Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, Kursk, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The aim of this study was to replicate associations of GWAS-significant loci with severe COVID-19 in the population of Central Russia, to investigate associations of the SNPs with thromboinflammation parameters, to analyze gene-gene and gene-environmental interactions. Materials and Methods: DNA samples from 798 unrelated Caucasian subjects from Central Russia (199 hospitalized COVID-19 patients and 599 controls with a mild or asymptomatic course of COVID-19) were genotyped using probe-based polymerase chain reaction for 10 GWAS-significant SNPs: rs143334143 Results: SNP rs17713054 Conclusion: Overall, this study represents a comprehensive molecular-genetic and bioinformatics analysis of the involvement of GWAS-significant loci in the molecular mechanisms of severe COVID-19, gene-gene and gene-environmental interactions, and provides evidence of their relationship with thromboinflammation parameters in patients hospitalized in intensive care units.

Indexed as

chronic diseasesCOVID-19genotypingGWASrs12610495rs17078346rs17713054thromboinflammation syndrome

Identifiers

PMID39175753
PMCPMC11338913

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.