Evidence map›Paper›PMID 39175522›Full record

ArticleNeuroImmune pharmacology and therapeutics2024

Sera from people with HIV and depression induce commensurate metabolic alterations in astrocytes: toward precision diagnoses and therapies.

Anna Elizabeth Laird, Alexandra Anh Le, Jacqueline R Kulbe, Anya Umlauf, Melody Sagarian, Matthew Spencer, Anish Sathe, David J Grelotti, Jennifer Iudicello, Brook Henry and 2 more

Abstract read
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In one paragraph

Article in NeuroImmune pharmacology and therapeutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Anna Elizabeth LairdDepartment of Psychiatry, University of California, San Diego, CA, USA.
Alexandra Anh LeDepartment of Psychiatry, University of California, San Diego, CA, USA.
Jacqueline R KulbeDepartment of Psychiatry, University of California, San Diego, CA, USA.
Anya UmlaufDepartment of Psychiatry, University of California, San Diego, CA, USA.
Melody SagarianDepartment of Psychiatry, University of California, San Diego, CA, USA.
Matthew SpencerDepartment of Psychiatry, University of California, San Diego, CA, USA.
Anish SatheDepartment of Psychiatry, University of California, San Diego, CA, USA.
David J GrelottiDepartment of Psychiatry, University of California, San Diego, CA, USA.
Jennifer IudicelloDepartment of Psychiatry, University of California, San Diego, CA, USA.
Brook HenryDepartment of Psychiatry, University of California, San Diego, CA, USA.
Ronald J EllisDepartment of Psychiatry, University of California, San Diego, CA, USA.
Jerel Adam FieldsDepartment of Psychiatry, University of California, San Diego, CA, USA.

Funding

Psychiatry Research Residency Training TrackR25MH101072 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NEAL R SWERDLOW · 2013 to 2026
$2.8M
The role of TFAM alterations in HIV- and ART-induced mitochondrial dysfunction in the brainR01MH128108 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jerel Adam Fields · 2022 to 2026
$2.3M
The role of TREM2 in Alzheimer's disease neuropathogenesis in HIV+ individualsR56AG066215 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIELDS, JEREL ADAM · 2020 to 2020
$749k
NIA NIH HHS R56 AG066215NIMH NIH HHS R01 MH128108NIMH NIH HHS R25 MH101072
6 · The paper itself

Abstract

Objectives: People with HIV (PWH) have high rates of depression and neurocognitive impairment (NCI) despite viral suppression on antiretroviral therapy (ART). Mounting evidence suggests that immunometabolic disruptions may contribute to these conditions in some PWH. We hypothesized that metabolic dysfunction in astrocytes is associated with depressive symptoms and cognitive function in PWH. Methods: Human astrocytes were exposed to sera from PWH ( Results: More severe depression, as indexed by higher Beck's Depression Inventory (BDI-II) scores, was associated with lower MT signal measures. Better cognitive function, as assessed by neuropsychiatric testing t-scores, was associated with increased MT signal measures. GFAP intensity negatively correlated with several cognitive t-scores. Age positively correlated with (higher) MT signal measures and GFAP intensity. Worse depressive symptoms (higher BDI-II scores) were associated with decreased oxygen consumption rate and spare respiratory capacity, concomitant with increased extracellular acidification rate in astrocytes. Conclusions: These findings show that factors in the sera of PWH alter mitochondrial activity in cultured human astrocytes, suggesting that mechanisms that alter mitochondrial and astrocyte homeostasis can be detected peripherally. Thus,

Indexed as

astrocytesdepressionHIVmetabolismneurocognitive impairmentneuroinflammation

Identifiers

PMID39175522
PMCPMC11338010

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.