Evidence map›Paper›PMID 39175203›Full record

ArticleCancer science2024

Tretinoin synergistically enhances the antitumor effect of combined BRAF, MEK, and EGFR inhibition in BRAF

Yuya Yoshida, Masanobu Takahashi, Sakura Taniguchi, Ryunosuke Numakura, Keigo Komine, Chikashi Ishioka

Abstract read
In one paragraph

Article in Cancer science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yuya YoshidaDepartment of Clinical Oncology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
Masanobu TakahashiDepartment of Clinical Oncology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.ORCID https://orcid.org/0000-0001-9306-7041
Sakura TaniguchiDepartment of Clinical Oncology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
Ryunosuke NumakuraDepartment of Clinical Oncology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
Keigo KomineDepartment of Medical Oncology, Tohoku University Hospital, Sendai, Miyagi, Japan.
Chikashi IshiokaDepartment of Clinical Oncology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.ORCID https://orcid.org/0000-0002-3023-1227

Funding

the Ministry of Education, Culture, Sports, Science, and Technology of Japan 18 K07993the Ministry of Education, Culture, Sports, Science, and Technology of Japan 21 K07169
6 · The paper itself

Abstract

Patients with BRAF-mutated colorectal cancer (BRAF

Indexed as

ApoptosisColorectal NeoplasmsDrug SynergismErbB ReceptorsProto-Oncogene Proteins B-rafTretinoinXenograft Model Antitumor AssaysAnimalsAntineoplastic Combined Chemotherapy ProtocolsCell Line, TumorCell ProliferationFemaleHumansMiceMice, NudeMutationBRAF protein, humanEGFR protein, humanErbB ReceptorsProtein Kinase InhibitorsProto-Oncogene Proteins B-rafTretinoinBRAF inhibitorcolorectal cancerMEK inhibitorretinoidtretinoin

Identifiers

PMID39175203
PMCPMC11531965

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.