Evidence map›Paper›PMID 39175111›Full record

SynthesisJournal of the American Geriatrics Society2025

Development of loneliness and social isolation after spousal loss: A systematic review of longitudinal studies on widowhood.

Kerri Niino, Molly A Patapoff, Brent T Mausbach, Hui Liu, Alison A Moore, Benjamin H Han, Barton W Palmer, Dylan J Jester

Abstract readSystematic Review
In one paragraph

Synthesis in Journal of the American Geriatrics Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Life after loss: gendered changes in social networks and community participation around widowhood.The journals of gerontology. Series B, Psychological sciences and social sciences · 2026
    Article
  3. Article
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kerri NiinoJohn A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA.ORCID 0000-0003-1989-9100
Molly A PatapoffSam and Rose Stein Institute for Research on Aging, University of California San Diego, La Jolla, California, USA.
Brent T MausbachDepartment of Psychiatry, University of California San Diego, La Jolla, California, USA.
Hui LiuCenter on Aging and the Life Course, Purdue University, West Lafayette, Indiana, USA.
Alison A MooreSam and Rose Stein Institute for Research on Aging, University of California San Diego, La Jolla, California, USA.
Benjamin H HanDivision of Geriatrics, Gerontology, and Palliative Care, Department of Medicine, University of California San Diego, La Jolla, California, USA.ORCID 0000-0001-6882-0142
Barton W PalmerDepartment of Psychiatry, University of California San Diego, La Jolla, California, USA.
Dylan J JesterWomen's Operational Military Exposure Network Center of Excellence (WOMEN CoE), VA Palo Alto Health Care System, Palo Alto, California, USA.ORCID 0000-0001-9878-9633

Funding

FELLOWSHIP IN GERIATRIC MENTAL HEALTHT32MH019934 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Elizabeth W Twamley · 1994 to 2026
$9.5M
Loneliness in Aging with SchizophreniaR01MH120201 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PALMER, BARTON W. · 2020 to 2024
$3.9M
UCSD Medical Student Summer Aging Research TrainingT35AG026757 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Benjamin Hyun Han, Ellen Eun-Ok Lee · 2005 to 2026
$2.2M
Marriage, Cognitive Trajectories and ADRD Risk in Late LifeR01AG061118 · NIA · PURDUE UNIVERSITY · PI LIU, HUI · 2019 to 2022
$1.1M
Measuring Social Isolation, Loneliness, and Intersectional Stigma among Older Adults with Opioid Use DisorderR21DA058404 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HAN, BENJAMIN HYUN, INAGAKI, TRISTEN K. · 2023 to 2024
$445k
NIA NIH HHS R01 AG061118NIA NIH HHS R01AG061118NIA NIH HHS T35 AG026757NIA NIH HHS T35AG26757NIDA NIH HHS R21 DA058404NIDA NIH HHS R21DA058404NIMH NIH HHS R01 MH120201NIMH NIH HHS R01MH120201NIMH NIH HHS T32 MH019934NIMH NIH HHS T32MH019934Sam and Rose Stein Institute for Research on Aging at UC San Diego
6 · The paper itself

Abstract

backgroundSpousal loss is a stressful life event that is associated with loneliness and social isolation, both of which affect mental and physical health. The primary objective of this paper was to synthesize longitudinal studies that investigated loneliness and social isolation in widowhood.

methodsA systematic search of the literature was conducted using three electronic databases. 26 longitudinal studies published through June 2024 were included for further analysis. Participant characteristics, study design, and key findings were extracted.

resultsMost studies were from the United States or Europe, included more widows than widowers, and assessed loneliness in older adults aged >60 years. Loneliness peaked directly following spousal death, but findings were inconsistent regarding the lasting effects of widowhood. Heterogeneity in the longitudinal trajectories of loneliness was noted, with studies showing linear increases, decreases, or curvilinear relationships over time. Several factors modified the relationship between widowhood and loneliness, including volunteerism, military experience, income, and age. Widowers consistently reported greater loneliness and worse social isolation when compared with widows. Few studies investigated social isolation specifically, but those that did found that social isolation may decrease in widowhood.

conclusionsAs the world grapples with a social pandemic of loneliness and social isolation, widowed adults may be uniquely affected. Few studies investigated the longitudinal trajectory of loneliness and especially social isolation in widowhood, and those that did found heterogenous results. Future work is needed to understand why some widowed adults are uniquely affected by feelings of loneliness and social isolation while others are not, and whether potentially modifiable factors that moderate or mediate this relationship could be leveraged by psychosocial interventions.

Indexed as

LonelinessSocial IsolationWidowhoodAgedFemaleHumansLongitudinal StudiesMaleMiddle Agedbereavementmental healthsocial disconnectionwidowhood

Identifiers

PMID39175111
PMCPMC11735283

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.