Evidence map›Paper›PMID 39175026›Full record

ReviewInternational journal of retina and vitreous2024

Large macular hole and autologous retinal transplantation: a systematic review and meta-analysis.

Mário Hanai, Dillan Cunha Amaral, Raiza Jacometti, Eduardo Henrique Cassins Aguiar, Fernando Cotrim Gomes, Laura Goldfarb Cyrino, Milton Ruiz Alves, Mário Luiz Ribeiro Monteiro, Raphaela Masetto Fuganti, Antonio Marcelo Barbante Casella and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of retina and vitreous, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mário HanaiFaculty of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Dillan Cunha AmaralFaculty of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Raiza JacomettiDivision of Ophthalmology and the Laboratory for Investigation in Ophthalmology (LIM-33), Faculty of Medicine, University of São Paulo, São Paulo, SP, Brazil.
Eduardo Henrique Cassins AguiarFaculty of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Fernando Cotrim GomesFaculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Laura Goldfarb CyrinoDivision of Ophthalmology and the Laboratory for Investigation in Ophthalmology (LIM-33), Faculty of Medicine, University of São Paulo, São Paulo, SP, Brazil.
Milton Ruiz AlvesDivision of Ophthalmology and the Laboratory for Investigation in Ophthalmology (LIM-33), Faculty of Medicine, University of São Paulo, São Paulo, SP, Brazil.
Mário Luiz Ribeiro MonteiroDivision of Ophthalmology and the Laboratory for Investigation in Ophthalmology (LIM-33), Faculty of Medicine, University of São Paulo, São Paulo, SP, Brazil.
Raphaela Masetto FugantiFaculty of Medicine, State University of Londrina, Londrina, PR, Brazil.
Antonio Marcelo Barbante CasellaFaculty of Medicine, State University of Londrina, Londrina, PR, Brazil.
Ricardo Noguera LouzadaDivision of Ophthalmology and the Laboratory for Investigation in Ophthalmology (LIM-33), Faculty of Medicine, University of São Paulo, São Paulo, SP, Brazil. louzadaricardo@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMacular holes are breaks in the retinal tissue at the center of the macula, affecting central vision. The standard treatment involves vitrectomy with membrane peeling and gas tamponade. However, for larger or chronic holes, alternative techniques like autologous retinal graft have emerged. This meta-analysis evaluates the efficacy and safety of retinal transplantation in managing large macular holes.

methodsWe conducted a systematic review and meta-analysis following PRISMA guidelines. The study was prospectively registered in PROSPERO (CRD42024504801). We searched PubMed, Web of Science, Cochrane, and Embase databases for observational studies including individuals with large macular holes with or without retinal detachments and retinal transplantation as the main therapy. We used a random-effects model to compute the mean difference with 95% confidence intervals and performed statistical analysis using R software.

resultsWe conducted a comprehensive analysis of 19 studies involving 322 patients diagnosed with various types of macular holes (MHs). These included cohorts with refractory MH, high myopia associated with MH, primary MH, and MH with retinal detachment (RD). The findings were promising, revealing an overall closure rate of 94% of cases (95% CI 88-98, I

conclusionART for large MH shows promising results, including significant improvements in visual acuity and a high rate of MH closure with low complication risks overall and for subgroups.

Indexed as

Autologous neurosensory retinal transplantationAutologous retinal transplantationLarge macular holeMacular holeNeurosensory retinal graftPersistent macular holeRecurrent macular holeRefractory macular holeRetinal transplantationVitrectomy

Identifiers

PMID39175026
PMCPMC11340077

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.