Evidence map›Paper›PMID 39175017›Full record

ArticleArchives of public health = Archives belges de sante publique2024

Implementing a Metabolism-informed approach for smoking cessation in an Alaska Tribal health system: study protocol for a single-arm implementation pilot trial.

Kelley J Jansen, Brianna N Tranby, Aliassa L Shane, Todd Takeno, Kelly Chadwick, Pamela Sinicrope, Jennifer L Shaw, Rachel F Tyndale, Jeffrey R Harris, Christi A Patten and 1 more

Abstract read
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In one paragraph

Article in Archives of public health = Archives belges de sante publique, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Kelley J JansenCenter for Alaska Native Health Research, University of Alaska Fairbanks, 2141 Koyukuk Dr, Fairbanks, AK, 99775, USA. Kjansen2@alaska.edu.
Brianna N TranbyDepartment of Psychiatry & Psychology, Mayo Clinic, Behavioral Health Research Program, 200 First Street SW, Rochester, MN, 55905, USA.
Aliassa L ShaneSouthcentral Foundation Research Department, 4085 Tudor Centre Drive, Anchorage, Alaska, 99508, USA.
Todd TakenoSouthcentral Foundation Research Department, 4085 Tudor Centre Drive, Anchorage, Alaska, 99508, USA.
Kelly ChadwickDepartment of Health Systems and Population Health, School of Public Health, Fourth Floor, University of Washington, 15 Ave NE, Box 351621, Seattle, WA, 98195, USA.
Pamela SinicropeDepartment of Psychiatry & Psychology, Mayo Clinic, Behavioral Health Research Program, 200 First Street SW, Rochester, MN, 55905, USA.
Jennifer L ShawCenter for Alaska Native Health Research, University of Alaska Fairbanks, 2141 Koyukuk Dr, Fairbanks, AK, 99775, USA.
Rachel F TyndaleCentre for Addiction and Mental Health and Departments of Pharmacology and Toxicology, and Psychiatry, University of Toronto, 1 King's College Circle, Room 4326, Toronto, ON, M5S 1A8, Canada.
Jeffrey R HarrisDepartment of Health Systems and Population Health, School of Public Health, Fourth Floor, University of Washington, 15 Ave NE, Box 351621, Seattle, WA, 98195, USA.
Christi A PattenDepartment of Psychiatry & Psychology, Mayo Clinic, Behavioral Health Research Program, 200 First Street SW, Rochester, MN, 55905, USA.
Jaedon P AveySouthcentral Foundation Research Department, 4085 Tudor Centre Drive, Anchorage, Alaska, 99508, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIndividualized treatment for commercial tobacco smoking cessation, such as through the utilization of the nicotine metabolite ratio (NMR), offers potential clinical benefit. NMR is a metabolism-informed biomarker that can be used to guide medication selection. NMR testing is particularly promising for tobacco cessation efforts in populations with high rates of smoking, such as some Alaska Native and American Indian (AN/AI) communities. To date, no prior study has evaluated the implementation of NMR-guided tobacco cessation with AN/AI populations.

methodsThe present "QUIT" protocol is a two-phase study that will occur at Southcentral Foundation (SCF), an Alaska Native-owned health system, serving 70,000 AN/AI people, based in Anchorage, Alaska. In Phase one, qualitative interviews with customer-owners (patients), providers and administrators (n = 36) and a 10-participant beta-test will be used to refine a strategy to implement NMR testing in the health system. Phase two will involve a single-arm pilot trial (n = 50) and qualitative interviews throughout data collection (n = 48) to evaluate the implementation strategy and explore the real-world acceptability and feasibility of NMR testing to guide tobacco cessation with AN/AI populations. DISCUSSION: This study utilizes a community-based participatory approach to refine and implement a nicotine metabolism-informed smoking cessation program in a Tribal healthcare setting. The process and findings from this study will reflect the importance of customer-owner choice and honor the lived experience involved in quitting commercial tobacco. Pilot study data will inform the effect and sample sizes required for a future pragmatic trial of NMR-guided smoking cessation.

trial registrationThis study will be registered with clinicaltrials.gov after the beta test is complete and the final IRB protocol is approved.

Indexed as

Alaska Native and American IndianHealth ServicesImplementationNicotine Metabolite RatioTobacco Cessation

Identifiers

PMID39175017
PMCPMC11340097

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.