Evidence map›Paper›PMID 39174942›Full record

ArticleBMC musculoskeletal disorders2024

Analysis and study on biomarkers of local muscle fatigue caused by repetitive lifting task.

Siwu Zhong, Ning Jia, Ying Qu, Xueyan Zhang, Qing Xu, Yan Yang, Zhi Wang, Zhongxu Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC musculoskeletal disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Effect ofFrontiers in medicine · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Siwu ZhongOccupational Health Surveillance Center, Guangzhou Twelfth People's Hospital, Guangzhou, 510620, China.
Ning JiaNational Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing, 100050, China.
Ying QuNational Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing, 100050, China.
Xueyan ZhangNational Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing, 100050, China.
Qing XuNational Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing, 100050, China.
Yan YangKey Laboratory of Occupational Environment and Health, Guangzhou Twelfth People's Hospital, Guangzhou, 510620, China.
Zhi WangKey Laboratory of Occupational Environment and Health, Guangzhou Twelfth People's Hospital, Guangzhou, 510620, China. zhi_wang@outlook.com.
Zhongxu Wang *National Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing, 100050, China. wangzx@niohp.chinacdc.cn.

Funding

Guangzhou Key Medical Discipline 2021-2023Key Research and Development Program of Guangzhou Science and Technology Project 202206010061National Key Research and Development Program of China 2022YFC2503205Project of Occupational Health Risk Assessment and National Occupational Health Standard Formulation of the National Institute of Occupational Health and Poison Control 131031109000160004The Science and Technology Program of Guangzhou 2023A03J0502
6 · The paper itself

Abstract

backgroundWork-related musculoskeletal disorders (WMSDs) show a rapid growth trend. It has brought a huge economic burden to the society and become a serious occupational health problem that needs to be solved urgently. This study aimed to analyze the local muscle response under continuous ergonomic load, screen sensitive fatigue-related biomarkers and provide data support for the early prevention of local muscle damage and the exploration of early warning indicators.

methodsThirteen male college student volunteers were recruited to perform simulated repetitive manual lifting tasks in the laboratory. The lifting task was designed for 4 periods which lasted for 12 min in each, and then paused for 3 min for sampling. Local muscle fatigue is assesed by the Rating of perceived exertion (RPE) and the Joint analysis of sEMG spectrum and amplitude (JASA). Elbow venous blood was collected and 14 kinds of biomarkers were analyzed, which included Metabolic markers Ammonia (AMM), Lactic acid (LAC), Creatine kinase (CK), Lactate dehydrogenase (LDH), Cartilage oligomeric matrix protein (COMP), C-telopeptide of collagen I and II (CTX-I, CTX-II) and Calcium ion (Ca

resultsBoth subjective and objective fatigue appeared at the same period. Serum AMM, LAC, CK, LDH, COMP, CTX-II, Ca

conclusionsMetabolic markers (serum AMM, LAC, CK, LDH, COMP, CTX-II, Ca

Indexed as

BiomarkersLiftingMuscle FatigueAdultCumulative Trauma DisordersHumansMaleMuscle, SkeletalYoung AdultBiomarkersBiomarkersMuscle fatigueMusculoskeletal diseases

Identifiers

PMID39174942
PMCPMC11342632

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.