Evidence map›Paper›PMID 39174884›Full record

ArticleZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences2024

Two-sample Mendelian randomization analysis of the causal relationship between blood eosinophils and allergic rhinitis.

Xinlong Li, Guohao Deng, Na Lin, Guolin Tan, Honghui Liu

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In one paragraph

Article in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Xinlong LiDepartment of Otolaryngology-Head and Neck Surgery, Third Xiangya Hospital, Central South University, Changsha 410013, China. 1308982281@qq.com.
Guohao DengDepartment of Otolaryngology-Head and Neck Surgery, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Na LinDepartment of Otolaryngology-Head and Neck Surgery, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Guolin TanDepartment of Otolaryngology-Head and Neck Surgery, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Honghui LiuDepartment of Otolaryngology-Head and Neck Surgery, Third Xiangya Hospital, Central South University, Changsha 410013, China. honghuiliucsu@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesPrevious studies have revealed a correlation between eosinophils and allergic rhinitis, but the causal relationship has not been fully confirmed. This study aims to evaluate the causal link between blood eosinophils and allergic rhinitis using the Mendelian randomization (MR) method.

methodsSummary data from the Genome-Wide Association Study Catalog (GWAS) for eosinophil count (exposure variable) and allergic rhinitis (outcome variable) were collected. GWAS data for the exposure variable were obtained from the IEU Open GWAS Project developed by the Integrative Epidemiology Unit at the University of Bristol, while data for the outcome variable were sourced from the FinnGen Biobank (Finland) database. The causal relationship between eosinophils and allergic rhinitis was analyzed using the two-sample MR method with inverse variance weighted (IVW) analysis. Sensitivity analyses were conducted using the weighted median method, MR-Egger regression, leave-one-out analysis, and funnel plots.

resultsAn increase in blood eosinophil count showed a potential causal relationship with an increased risk of allergic rhinitis (

conclusionsThere is a causal association between increased eosinophil count and a higher risk or worsening of allergic rhinitis.

Indexed as

EosinophilsGenome-Wide Association StudyMendelian Randomization AnalysisPolymorphism, Single NucleotideRhinitis, AllergicHumansLeukocyte CountRisk Factorsallergic rhinitiscausal analysiseosinophilsMendelian randomizationsingle nucleotide polymorphism

Identifiers

PMID39174884
PMCPMC11341226

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