Evidence map›Paper›PMID 39174863›Full record

ArticleMolecular systems biology2024

Highly parallelized laboratory evolution of wine yeasts for enhanced metabolic phenotypes.

Payam Ghiaci, Paula Jouhten, Nikolay Martyushenko, Helena Roca-Mesa, Jennifer Vázquez, Dimitrios Konstantinidis, Simon Stenberg, Sergej Andrejev, Kristina Grkovska, Albert Mas and 4 more

Abstract read
In one paragraph

Article in Molecular systems biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Payam GhiaciDepartment of Chemistry and Molecular Biology, University of Gothenburg, PO Box 462, Gothenburg, 40530, Sweden.
Paula JouhtenEuropean Molecular Biology Laboratory, Heidelberg, 69117, Germany.ORCID http://orcid.org/0000-0003-1075-7448
Nikolay MartyushenkoDepartment of Biotechnology and Food Science, NTNU - Norwegian University of Science and Technology, Trondheim, Norway.
Helena Roca-MesaUniversitat Rovira i Virgili, Dept. Bioquímica i Biotecnologia, Facultat d'Enologia, Tarragona, 43007, Spain.
Jennifer VázquezUniversitat Rovira i Virgili, Dept. Bioquímica i Biotecnologia, Facultat d'Enologia, Tarragona, 43007, Spain.
Dimitrios KonstantinidisEuropean Molecular Biology Laboratory, Heidelberg, 69117, Germany.
Simon StenbergDepartment of Chemistry and Molecular Biology, University of Gothenburg, PO Box 462, Gothenburg, 40530, Sweden.
Sergej AndrejevEuropean Molecular Biology Laboratory, Heidelberg, 69117, Germany.
Kristina GrkovskaEuropean Molecular Biology Laboratory, Heidelberg, 69117, Germany.ORCID http://orcid.org/0000-0002-3784-494X
Albert MasUniversitat Rovira i Virgili, Dept. Bioquímica i Biotecnologia, Facultat d'Enologia, Tarragona, 43007, Spain.ORCID http://orcid.org/0000-0002-0763-1679
Gemma BeltranUniversitat Rovira i Virgili, Dept. Bioquímica i Biotecnologia, Facultat d'Enologia, Tarragona, 43007, Spain.
Eivind AlmaasDepartment of Biotechnology and Food Science, NTNU - Norwegian University of Science and Technology, Trondheim, Norway. eivind.almaas@ntnu.no.ORCID http://orcid.org/0000-0002-9125-326X
Kiran R PatilEuropean Molecular Biology Laboratory, Heidelberg, 69117, Germany. kp533@cam.ac.uk.ORCID http://orcid.org/0000-0002-6166-8640
Jonas WarringerDepartment of Chemistry and Molecular Biology, University of Gothenburg, PO Box 462, Gothenburg, 40530, Sweden. jonas.warringer@cmb.gu.se.ORCID http://orcid.org/0000-0001-6144-2740

Funding

Bundesministerium für Bildung und Forschung (BMBF) 031A605EC | ERC | HORIZON EUROPE European Research Council (ERC) 866028Ministerio de Ciencia e Innovación (MCIN) PCI2018-092962Norges Forskningsråd (Forskningsrådet) 245160Research Council of Finland (AKA) 310514,314125,329930Vetenskapsrådet (VR) 325-2014-6547
6 · The paper itself

Abstract

Adaptive Laboratory Evolution (ALE) of microorganisms can improve the efficiency of sustainable industrial processes important to the global economy. However, stochasticity and genetic background effects often lead to suboptimal outcomes during laboratory evolution. Here we report an ALE platform to circumvent these shortcomings through parallelized clonal evolution at an unprecedented scale. Using this platform, we evolved 10

Indexed as

FermentationPhenotypeSaccharomyces cerevisiaeWineClonal EvolutionDirected Molecular EvolutionEvolutionary EngineeringExperimental EvolutionFermentationMetabolismYeast

Identifiers

PMID39174863
PMCPMC11450223

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.