Evidence map›Paper›PMID 39174858›Full record

ArticleOncogene2024

Identification of a novel alternative splicing isoform of the Hippo kinase STK3/MST2 with impaired kinase and cell growth suppressing activities.

Ana Maria Rodrigues, Ana Paula Zen Petisco Fiore, Gabriela D A Guardia, Rebeka Tomasin, André Azevedo Reis Teixeira, Ricardo Jose Giordano, Deborah Schechtman, Michele Pagano, Pedro A F Galante, Alexandre Bruni-Cardoso

Abstract read
PubMed Publisher
In one paragraph

Article in Oncogene, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ana Maria RodriguesDepartamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Brazil.
Ana Paula Zen Petisco FioreDepartamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Brazil.
Gabriela D A GuardiaCentro de Oncologia Molecular, Hospital Sírio-Libanês, São Paulo, Brazil.ORCID 0000-0002-1789-2768
Rebeka TomasinDepartamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Brazil.
André Azevedo Reis TeixeiraDepartamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Brazil.
Ricardo Jose GiordanoDepartamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Brazil.ORCID 0000-0001-8116-6771
Deborah SchechtmanDepartamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Brazil.
Michele PaganoDepartment of Biochemistry and Molecular Pharmacology, Howard Hughes Medical Institute, New York University Grossman School of Medicine, New York, NY, USA.ORCID 0000-0003-3210-2442
Pedro A F GalanteCentro de Oncologia Molecular, Hospital Sírio-Libanês, São Paulo, Brazil.ORCID 0000-0002-4820-4155
Alexandre Bruni-CardosoDepartamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Brazil. brunicar@iq.usp.ORCID 0000-0003-3475-2190

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mammalian Ste-20-like Kinases 1 and 2 (MST1/2) are core serine-threonine kinases of the Hippo pathway regulating several cellular processes, including cell cycle arrest and cell death. Here, we discovered a novel alternative splicing variant of the MST2 encoding gene, STK3, in malignant cells and tumor datasets. This variant, named STK3

Indexed as

Alternative SplicingCell ProliferationProtein Serine-Threonine KinasesSerine-Threonine Kinase 3Adaptor Proteins, Signal TransducingCell Line, TumorExonsHEK293 CellsHepatocyte Growth FactorHippo KinasesHumansNeoplasmsPhosphorylationProtein IsoformsUbiquitinationUbiquitin-Protein LigasesAdaptor Proteins, Signal TransducingHepatocyte Growth FactorHippo KinasesMOB1A protein, humanProtein IsoformsProtein Serine-Threonine KinasesSerine-Threonine Kinase 3STK3 protein, humanUbiquitin-Protein Ligases

Identifiers

PMID39174858

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.