Evidence map›Paper›PMID 39174702›Full record

ArticleAAPS PharmSciTech2024

Microbicidal Polymer Nanoparticles Containing Clotrimazole for Treatment of Vulvovaginal Candidiasis.

María Del Rocío Lara-Sánchez, Adriana Ganem-Rondero, María Guadalupe Nava-Arzaluz, Andrea Angela Becerril-Osnaya, Laura Abril Pérez-Carranza, Sergio Alcalá-Alcalá, Néstor Mendoza-Muñoz, Elizabeth Piñón-Segundo

Erratum issuedAbstract read
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In one paragraph

Article in AAPS PharmSciTech, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

María Del Rocío Lara-SánchezLaboratorio de Sistemas Farmacéuticos de Liberación Modificada (L-13, UIM), Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de México, 54714, Estado de México, Mexico.
Adriana Ganem-RonderoLaboratorio de Investigación y Posgrado en Tecnología Farmacéutica (L-322, Campo 1), Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de México, 54740, Estado de México, Mexico.
María Guadalupe Nava-ArzaluzLaboratorio de Investigación y Posgrado en Tecnología Farmacéutica (L-322, Campo 1), Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de México, 54740, Estado de México, Mexico.
Andrea Angela Becerril-OsnayaLaboratorio de Microbiología (Anexo L-513, Campo 1), Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de México, 54740, Cuautitlán Izcalli, Mexico.
Laura Abril Pérez-CarranzaLaboratorio de Microbiología (Anexo L-513, Campo 1), Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de México, 54740, Cuautitlán Izcalli, Mexico.
Sergio Alcalá-AlcaláLaboratorio de Tecnología Farmacéutica, Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Cuernavaca, 62209, México.
Néstor Mendoza-MuñozLaboratorio de Farmacia, Facultad de Ciencias Químicas, Universidad de Colima, Colima, 28040, México.
Elizabeth Piñón-SegundoLaboratorio de Sistemas Farmacéuticos de Liberación Modificada (L-13, UIM), Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de México, 54714, Estado de México, Mexico. pinonsegundoelizabeth@cuautitlan.unam.mx.ORCID http://orcid.org/0000-0002-4172-6233

Funding

Consejo Nacional de Ciencia y Tecnología 245488
6 · The paper itself

Abstract

Vulvovaginal candidiasis (VVC) alters the innate cervicovaginal immunity, which provides an important barrier against viruses and other infections. The incidence of this disease has not decreased in the last 30 years, so effective treatments are still needed. Nanoparticles (NPs) of cellulose acetate phthalate (CAP) and clotrimazole (CLZ) were prepared by the emulsification-diffusion method. NPs were characterized using dynamic light scattering, atomic force microscopy and differential scanning calorimetry; their release profile was determined by the dialysis bag technique and mucoadhesion was evaluated with the mucin-particle method. The growth inhibition study of Candida albicans was carried out using the plate counting technique. Finally, accelerated physical stability tests of NPs were carried out, both in water and in SVF. The CAP-CLZ NPs had an average diameter of 273.4 nm, a PDI of 0.284, smooth surfaces and spherical shapes. In vitro release of CLZ from the CAP NPs was categorized with the Weibull model as a matrix system in which initial release was rapid and subsequently sustained. The inhibition of C. albicans growth by the CAP-CLZ NPs was greater than that of free CLZ, and the CAP-only NPs had a microbicidal effect on C. albicans. The NPs showed poor mucoadhesiveness, which could lead to studies of their mucopenetration capacities. An accelerated physical stability test revealed the erosion of CAP in aqueous media. A nanoparticulate system was developed and provided sustained release of CLZ, and it combined an antifungal agent with a microbial polymer that exhibited antifungal activity against C. albicans.

Indexed as

Antifungal AgentsCandida albicansCandidiasis, VulvovaginalCelluloseClotrimazoleNanoparticlesDrug LiberationMicrobial Sensitivity TestsParticle SizePolymersAntifungal AgentsCellulosecellulose acetate phthalateClotrimazolePolymersCandida albicansCellulose acetate phthalateClotrimazolePolymeric nanoparticlesVulvovaginal candidiasis

Identifiers

PMID39174702

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.