Evidence map›Paper›PMID 39174657›Full record

ArticleScientific reports2024

The diagnostic potential of urine in paediatric patients undergoing initial treatment for tuberculous meningitis.

Simon Isaiah, Johan A Westerhuis, Du Toit Loots, Regan Solomons, Marceline Tutu van Furth, Sabine van Elsland, Martijn van der Kuip, Shayne Mason

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Simon IsaiahHuman Metabolomics, Faculty of Natural and Agricultural Sciences, North‒West University, Potchefstroom, South Africa.
Johan A WesterhuisBiosystems Data Analysis, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands.
Du Toit LootsHuman Metabolomics, Faculty of Natural and Agricultural Sciences, North‒West University, Potchefstroom, South Africa.
Regan SolomonsDepartment of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Marceline Tutu van FurthPediatric Infectious Diseases and Immunology, Vrije Universiteit, Amsterdam University Medical Centers, Emma Children's Hospital, De Boelelaan 1117, Amsterdam, The Netherlands.
Sabine van ElslandDepartment of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Martijn van der KuipPediatric Infectious Diseases and Immunology, Vrije Universiteit, Amsterdam University Medical Centers, Emma Children's Hospital, De Boelelaan 1117, Amsterdam, The Netherlands.
Shayne MasonHuman Metabolomics, Faculty of Natural and Agricultural Sciences, North‒West University, Potchefstroom, South Africa. nmr.nwu@gmail.com.

Funding

National Research Foundation 120209
6 · The paper itself

Abstract

Tuberculous meningitis (TBM)-the extrapulmonary form of tuberculosis, is the most severe complication associated with tuberculosis, particularly in infants and children. The gold standard for the diagnosis of TBM requires cerebrospinal fluid (CSF) through lumbar puncture-an invasive sample collection method, and currently available CSF assays are often not sufficient for a definitive TBM diagnosis. Urine is metabolite-rich and relatively unexplored in terms of its potential to diagnose neuroinfectious diseases. We used an untargeted proton magnetic resonance (

Indexed as

Tuberculosis, MeningealAdolescentBiomarkersChildChild, PreschoolFemaleHumansInfantMaleMetabolomicsROC CurveBiomarkersDiagnosticMetabolomicsPediatricProton magnetic resonance (1H-NMR)Tuberculous meningitis (TBM)Urine

Identifiers

PMID39174657
PMCPMC11341861

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.