ArticleNature communications2024
Enhanced metabolic entanglement emerges during the evolution of an interkingdom microbial community.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed.
- Low initial metabolite production enhances stability in syntrophic bacterial consortia.Communications biology · 2026Article
- Dual-channel graph learning reveals similarity and complementarity in protein-protein interaction networks.PLoS computational biology · 2026Article
- Experimental Sodalis infection eliminates ancient insect symbiont.Nature communications · 2026Article
- Limits to the evolution of metabolic dependency in spatially structured microbial communities.iScience · 2026Article
- Collective dynamics ofmBio · 2025Article
- Control of flagellar gene expression by a chemotaxis receptor-like regulator in pathogenic Escherichia coli.The EMBO journal · 2025Article
- Strengthen or Weaken: Evolutionary Directions of Cross-Feeding After Formation.Environmental microbiology reports · 2025Review
- Uptake and leakage rates differentially shape community arrangement and composition of microbial consortia.The ISME journal · 2025Article
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Authors and funding
7 authors.
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Abstract
While different stages of mutualism can be observed in natural communities, the dynamics and mechanisms underlying the gradual erosion of independence of the initially autonomous organisms are not yet fully understood. In this study, by conducting the laboratory evolution on an engineered microbial community, we reproduce and molecularly track the stepwise progression towards enhanced partner entanglement. We observe that the evolution of the community both strengthens the existing metabolic interactions and leads to the emergence of de novo interdependence between partners for nitrogen metabolism, which is a common feature of natural symbiotic interactions. Selection for enhanced metabolic entanglement during the community evolution repeatedly occurred indirectly, via pleiotropies and trade-offs within cellular regulatory networks, and with no evidence of group selection. The indirect positive selection of metabolic dependencies between microbial community members, which results from the direct selection of other coupled traits in the same regulatory network, may therefore be a common but underappreciated driving force guiding the evolution of natural mutualistic communities.
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