ArticleEuropean heart journal. Quality of care & clinical outcomes2025
Diverticular disease and risk of incident major adverse cardiovascular events: a nationwide matched cohort study.
Article in European heart journal. Quality of care & clinical outcomes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Diverticular disease increases the risk of acute myocardial infarction.Przeglad gastroenterologiczny · 2026Review
- Increased Risk of Cardiovascular Events After Coronary Interventions in Inflammatory Bowel Disease: A Nationwide Matched Cohort Study.Alimentary pharmacology & therapeutics · 2025Article
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9 authors.
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Abstract
backgroundAn increased risk of cardiovascular disease (CVD) has been reported in patients with diverticular disease (DD). However, there are knowledge gaps about specific risks of each major adverse cardiovascular event (MACE) component. METHODS AND
resultsThis nationwide cohort study included Swedish adults with DD (1987-2017, N = 52 468) without previous CVD. DD was defined through ICD codes in the National Patient Register and colorectal histopathology reports from the ESPRESSO study. DD cases were matched by age, sex, calendar year, and county of residence to ≤5 population reference individuals (N = 194 525). Multivariable-adjusted hazard ratios (aHRs) for MACE up until December 2021 were calculated using stratified Cox proportional hazard models. Median age at DD diagnosis was 62 years, and 61% were females. During a median follow-up of 8.6 years, 16 147 incident MACE occurred in individuals with DD and 48 134 in reference individuals [incidence rates (IRs)= 61.4 vs. 43.8/1000 person-years], corresponding to an aHR of 1.24 (95%CI = 1.22-1.27), equivalent to one extra case of MACE for every 6 DD patients followed for 10 years. The risk was increased for ischaemic heart disease (IR = 27.9 vs. 18.6; aHR = 1.36, 95%CI = 1.32-1.40), congestive heart failure (IR = 23.2 vs. 15.8; aHR = 1.26, 95%CI = 1.22-1.31), and stroke (IR = 18.0 vs. 13.7; aHR = 1.15, 95%CI = 1.11-1.19). DD was not associated with cardiovascular mortality (IR = 18.9 vs. 15.3; aHR = 1.01, 95%CI = 0.98-1.05). Results remained robust in sibling-controlled analyses.
conclusionsPatients with DD had a 24% increased risk of MACE compared with reference individuals, but no increased cardiovascular mortality. Future research should confirm these data and examine underlying mechanisms and shared risk factors between DD and CVD.
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