Evidence map›Paper›PMID 39173693›Full record

ArticleNeuroImage2024

Quantitative gradient recalled echo (qGRE) MRI enables in vivo measurement of pre-atrophic neurodegeneration in a mouse model of Alzheimer's disease.

Michal R Tomaszewski, Alexander L Sukstanskii, Hyking Haley, Xiangjun Meng, Corin O Miller, Dmitriy A Yablonskiy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Michal R TomaszewskiTranslational Imaging Department, Merck & Co., Inc., Rahway, NJ, USA. Electronic address: michal.tomaszewski@merck.com.
Alexander L SukstanskiiMallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, MO, United States.
Hyking HaleyTranslational Imaging Department, Merck & Co., Inc., Rahway, NJ, USA.
Xiangjun MengTranslational Imaging Department, Merck & Co., Inc., Rahway, NJ, USA.
Corin O MillerTranslational Imaging Department, Merck & Co., Inc., Rahway, NJ, USA.
Dmitriy A YablonskiyMallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, MO, United States.

Funding

In vivo MRI Biomarkers of Microstructural Correlates of Brain Pathology in Preclinical and Early Alzheimer DiseaseR01AG054513 · NIA · WASHINGTON UNIVERSITY · PI YABLONSKIY, DMITRIY A · 2017 to 2021
$2.7M
In vivo Identification of Pre-Atrophic Brain Neurodegeneration in Prodromal Alzheimer Disease with Quantitative Gradient Recalled Echo MRIRF1AG077658 · NIA · WASHINGTON UNIVERSITY · PI YABLONSKIY, DMITRIY A · 2022 to 2022
$2.2M
Deep-Learning-Augmented Quantitative Gradient Recalled Echo (DLA-qGRE) MRI for in vivo Clinical Evaluation of Brain Microstructural Neurodegeneration in Alzheimer DiseaseRF1AG082030 · NIA · WASHINGTON UNIVERSITY · PI GOYAL, MANU S, YABLONSKIY, DMITRIY A · 2023 to 2023
$2.0M
In vivo Identification of Pre-Atrophic Brain Neurodegeneration in Prodromal Alzheimer Disease with Quantitative Gradient Recalled Echo MRIR01AG077658 · NIA · WASHINGTON UNIVERSITY · PI DMITRIY A YABLONSKIY · 2025 to 2026
$1.4M
NIA NIH HHS R01 AG054513NIA NIH HHS R01 AG077658NIA NIH HHS RF1 AG077658NIA NIH HHS RF1 AG082030
6 · The paper itself

Abstract

Robust methods are needed for preclinical evaluation of novel Alzheimer Disease (AD) therapies to accelerate drug discovery. Quantitative Gradient Recalled Echo (qGRE) MRI has shown promise to provide insight into neurodegeneration in AD prior to atrophy development in humans, highlighting areas of low neuronal density. In this study a novel qGRE method (20 echoes, TE=2-40ms) is shown to non-invasively measure the longitudinal neuronal loss in the hippocampus of a mouse model of AD tauopathy Tg4510. Tg4510 (n=10) and wild type (WT, n=6) mice underwent MRI (7T field strength) at 3-7 months old. 3D qGRE approach was used to generate brain-specific R

Indexed as

Alzheimer DiseaseDisease Models, AnimalMagnetic Resonance ImagingMice, TransgenicAnimalsAtrophyFemaleHippocampusMaleMiceAlzheimer's diseaseMRINeurodegenerationNeuronal densityQGRETg4510

Identifiers

PMID39173693
PMCPMC12237143

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.