Evidence map›Paper›PMID 39173446›Full record

ArticleClinical biomechanics (Bristol, Avon)2024

Knee muscle strength and steadiness for individuals with anterior cruciate ligament reconstruction and knee osteoarthritis.

Nicholas L Hunt, Matthew V Robinett, Tyler N Brown

Abstract read
In one paragraph

Article in Clinical biomechanics (Bristol, Avon), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Nicholas L HuntBiomedical Engineering Doctorate Program, Boise State University, Boise, ID, USA.
Matthew V RobinettDepartment of Kinesiology, Boise State University, Boise, ID, USA.
Tyler N BrownBiomedical Engineering Doctorate Program, Boise State University, Boise, ID, USA. Electronic address: tynbrown@boisestate.edu.

Funding

Women's health: interplay of maternal diet and key demographics on neurological health in the rural frontier and remote WestP20GM103408 · NIGMS · UNIVERSITY OF IDAHO · PI Carolyn Hovde Bohach · 2012 to 2026
$59.8M
VPS35 D620N inhibits autophagy through disrupted hyaluronic acid-CD44 signalingP20GM109095 · NIGMS · BOISE STATE UNIVERSITY · PI OXFORD, JULIA THOM · 2014 to 2023
$22.7M
Optimizing Deep Brain Stimulation for Parkinson's Disease.P20GM148321 · NIGMS · BOISE STATE UNIVERSITY · PI Paul Henry Davis · 2023 to 2026
$10.2M
Center of Biomedical Research Excellence in Matrix Biology Phase 3P30GM154497 · NIGMS · BOISE STATE UNIVERSITY · PI JULIA THOM OXFORD · 2024 to 2026
$4.2M
Musculoskeletal adaptation of young and older adults in response to environmental, physical, and cognitive conditionsR15AG059655 · NIA · BOISE STATE UNIVERSITY · PI FITZPATRICK, CLARE · 2018 to 2018
$410k
NIA NIH HHS R15 AG059655NIGMS NIH HHS P20 GM103408NIGMS NIH HHS P20 GM109095NIGMS NIH HHS P20 GM148321NIGMS NIH HHS P30 GM154497
6 · The paper itself

Abstract

backgroundStrength and neuromuscular decrements following knee musculoskeletal injury may accelerate knee osteoarthritis development. This study assessed isometric knee extensor and flexor strength and steadiness between individuals with knee injury, i.e., ligament reconstruction, and knee osteoarthritis to healthy age-matched controls.

methodsFour cohorts (1: knee injury and 2: age-matched controls, and 3: radiographic knee osteoarthritis and 4: age-matched controls) were recruited. Participants performed maximal voluntary isometric knee extensor and flexor contractions. Then, strength (e.g., peak and rate of torque development) and steadiness (e.g., peak power, mean, and median frequency) were derived from each raw torque-time curve and associated power spectral density. A Kruskal-Wallis H test and Spearman's rho correlation analysis assessed cohort differences and association between knee extensor and flexor strength and steadiness.

findingsThe young adult control and knee injury cohorts exhibited greater knee extensor and flexor strength than the older, knee osteoarthritis cohort (p < 0.043). The knee injury cohort, despite being as strong as their healthy counterparts, were significantly less steady with a 92% increase in peak power frequency (p = 0.046). The osteoarthritis cohort exhibited 157% less total power compared to the knee injury and young control cohorts (p < 0.019). Knee extensor and flexor peak torque, rate of torque development, and mean torque exhibit a significant, positive relation with total power (p < 0.018).

interpretationIndividuals with knee injury and disease may exhibit weaker or less steady knee musculature, predisposing them to degenerative joint disease. Clinicians may need to restore knee extensor and flexor steadiness to facilitate better joint neuromuscular control.

Indexed as

Muscle StrengthOsteoarthritis, KneeAdultAgedAnterior Cruciate LigamentAnterior Cruciate Ligament ReconstructionFemaleHumansIsometric ContractionKnee InjuriesKnee JointMaleMiddle AgedMuscle, SkeletalTorqueYoung AdultACL reconstructionBiomechanicsKneeOsteoarthritisSteadiness

Identifiers

PMID39173446
PMCPMC11414746

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.