ArticleNeurology2024
Association of Seizure Control With Cognition in People With Normal Cognition and Mild Cognitive Impairment.
Article in Neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Serum insulin-like growth factor-1 and its association with epilepsy risk and cognitive function.Acta epileptologica · 2026Article
- Assessing cognitive impairment in epilepsy using Arterial spin-labeled (ASL) perfusion imaging.Brain imaging and behavior · 2026Article
- Between Epilepsy and Neurodegeneration: The Hidden Architecture of Late-Onset Unexplained Epilepsy.Epilepsy currents · 2026Article
- Co-morbid seizures in frontotemporal dementia: MRI and PET correlations.Epilepsy & behavior reports · 2026Article
- From Cortex to Context: Rethinking Late-Onset Epilepsy Risk.Epilepsy currents · 2026Article
- Antiseizure Medications in Older Adults with Epilepsy: Considerations in Pharmacology, Safety, Tolerability, and Effectiveness of Newer Agents.Drugs & aging · 2026Review
- Chidamide Is Screened to Suppress Epileptogenesis in Mice Models via Blocking Histone Deacetylase 1.CNS neuroscience & therapeutics · 2026Article
- Epilepsy in the Aging Brain: Time to Rethink the Narrative.Epilepsy currents · 2026Article
- Gastrodin alleviates mild cognitive impairment and Alzheimer's disease via candidate targeting of ACHE, S1PR5, SERPINE1, and TOP2A: an integrative computational and cellular study.Frontiers in pharmacology · 2026Article
- Mesial temporal shape asymmetry as a neuro-imaging correlate of epilepsy in mild cognitive impairment and dementia.Brain communications · 2026Article
- The impact of long-term antiseizure treatment on cognitive decline in late-onset epileptic prodromal Alzheimer's disease: an exploratory study.Frontiers in aging neuroscience · 2026Article
- Co-morbid seizures in frontotemporal dementia: What do they tell us?Epilepsy research · 2025Article
- Clinical and Cognitive Profiles of Individuals with Alzheimer's Disease and Comorbid Seizures.Annals of neurology · 2025Article
- Active Seizures Predict Worse Instrumental Activities of Daily Living in Individuals With Normal Cognition and Dementia.Annals of clinical and translational neurology · 2025Article
- Seizing the link: Exploring the potential association between anti-seizure medications and Alzheimer's disease.Journal of Alzheimer's disease : JAD · 2025Article
- The association of seizure control with neuropathology in dementia.Brain : a journal of neurology · 2025Article
- Exploring biomarkers of neurodegeneration in epilepsy: Critical insights.Epileptic disorders : international epilepsy journal with videotape · 2025Review
- Risk Factors Associated With Late-Onset Epilepsy in Dementia and Mild Cognitive Impairment.JAMA neurology · 2025Article
- Seizure frequency, APOE ε4, and cognitive function in older people with epilepsy.Acta epileptologica · 2025Article
- The Bidirectional Relationship Between Epilepsy and Alzheimer's Disease.Current neurology and neuroscience reports · 2025Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
BACKGROUND AND
objectivesSeizures are common in dementia and associated with accelerated cognitive decline. However, the impact of active vs remote seizures on cognition remains understudied. This study aimed to investigate the impact of active vs remote seizures on cognition in people with normal cognition and mild cognitive impairment (MCI).
methodsThis longitudinal, multicenter cohort is based on National Alzheimer's Coordinating Center data of participants recruited from 39 Alzheimer's Disease Centers in the United States from September 2005 to December 2021. All participants with normal cognition and MCI and at least 2 visits were included. Primary outcome, that is, cognitive decline, was determined using Clinical Dementia Rating (CDR) from (1) normal-to-impaired (CDR ≥0.5) and (2) MCI-to-dementia (CDR ≥1) groups. The effect of active seizures (over the preceding 12 months), remote seizures (previous seizures but none over the preceding 12 months), and no seizures (controls) on cognition was assessed. Subgroups of chronic seizures at enrollment and new-onset seizures were further analyzed. Cox regression models assessed the risk of all-cause MCI and/or dementia. All models were adjusted for age, sex, education, race, hypertension, and diabetes.
resultsOf the 13,726 participants with normal cognition at enrollment (9,002 [66%] female; median age 71 years), 118 had active seizures and 226 had remote seizures. Of the 11,372 participants with MCI at enrollment (5,605 [49%] female; median age 73 years), 197 had active seizures and 226 had remote seizures. Active seizures were associated with 2.1 times higher risk of cognitive impairment (adjusted hazard ratio [aHR] 2.13, 95% CI 1.60-2.84, DISCUSSION: In this study, active seizures but not remote seizures were associated with earlier cognitive decline in both cognitively normal adults and those with MCI, independent of other dementia risk factors. Therefore, early identification and management of seizures may present a path to mitigation of cognitive decline in the aging epileptic population. A limitation is that causality cannot be confirmed in our observational longitudinal study.
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