ArticlePloS one2024
The relationship between mechanical power normalized to dynamic lung compliance and weaning outcomes in mechanically ventilated patients.
Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Article
- The predictive value of serological markers for successful weaning and 30-day mortality in patients with severe intracerebral hemorrhage.BMC neurology · 2026Article
- Mechanical power normalized to dynamic lung compliance as a predictor of weaning and prognosis in mechanically ventilated patients: a retrospective cohort study.BMC anesthesiology · 2025Observational
- The association of ventilator mechanical power with weaning outcomes in intensive care unit patients: a narrative review.Journal of thoracic disease · 2025Review
- Therapeutic outcomes and inflammatory modulation of inhaled N-acetylcysteine bronchoalveolar lavage in severe pneumonia.American journal of translational research · 2025Article
- Effects of secular changes in tidal volume and respiratory rate on the mechanical power of ventilation: a retrospective single-center study of invasively ventilated patients.Critical care science · 2025Article
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Authors and funding
7 authors.
Funding
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Abstract
backgroundProlonged mechanical ventilation is associated with an increased risk of mortality in these patients. However, there exists a significant clinical need for novel indicators that can complement traditional weaning evaluation methods and effectively guide ventilator weaning.
objectivesTo investigate the specific relationship between mechanical power normalized to dynamic lung compliance (Cdyn-MP) and weaning outcomes in patients on mechanical ventilation for more than 24 hours, as well as those who underwent a T-tube weaning strategy.
methodsA retrospective cohort study was conducted using the Medical Information Mart for Intensive Care-IV v1.0 database (MIMIC-IV v1.0). Patients who received invasive mechanical ventilation for more than 24 hours and underwent a T-tube ventilation strategy for weaning were enrolled. Patients were divided into two groups based on their weaning outcome: weaning success and failure. Ventilation parameter data were collected every 4 hours during the first 24 hours before the first spontaneous breathing trial (SBT).
resultsOf all the 3,695 patients, 1,421 (38.5%) experienced weaning failure. Univariate logistic regression analysis revealed that the risk of weaning failure increased as the Cdyn-MP level rose (OR 1.34, 95% CI 1.31-1.38, P<0.001). After adjusting for age, body mass index, disease severity, and pre-weaning disease status, patients with high Cdyn-MP quartiles in the 4 hours prior to the SBT had a significantly greater risk of weaning failure than those with low Cdyn-MP quartiles (odds ratio 10.37, 95% CI 7.56-14.24). These findings were robust and consistent in both subgroup and sensitivity analyses.
conclusionThe increased Cdyn-MP before SBT was independently associated with a higher risk of weaning failure in mechanically ventilated patients. Cdyn-MP has the potential to be a useful indicator for guiding the need for ventilator weaning and complementing traditional weaning evaluation methods.
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