ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2025
Timing of Influenza Antiviral Therapy and Risk of Death in Adults Hospitalized With Influenza-Associated Pneumonia, Influenza Hospitalization Surveillance Network (FluSurv-NET), 2012-2019.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Therapeutic effects of traditional Chinese medicine injections with heat-clearing and detoxifying properties on viral pneumonia: a systematic review and network meta-analysis.Frontiers in pharmacology · 2026Pooled it
- Prevalence and Outcomes of Bacterial Co-detections by Blood Culture Among Children and Adults Hospitalized With Laboratory-confirmed Influenza, Influenza Hospitalization Surveillance Network, 2022-2024.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026Article
- Influenza.Nature reviews. Disease primers · 2026Review
- Charting new territory: outpatient stewardship in immunocompromised patients (first of a two-part series).Antimicrobial stewardship & healthcare epidemiology : ASHE · 2026Review
- Construction of an auxiliary diagnostic model for secondary pulmonary bacterial infection in influenza based on routine detection indicators.American journal of translational research · 2026Article
- Article
- Antiviral Use Among Children Hospitalized With Laboratory-Confirmed Influenza Illness: A Prospective, Multicenter Surveillance Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025Article
- Benefit of Early Oseltamivir Therapy for Adults Hospitalized With Influenza A: An Observational Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025Observational
- Oseltamivir Treatment vs Supportive Care for Seasonal Influenza Requiring Hospitalization.JAMA network open · 2025Article
- Point of Care Nucleic Acid Testing for Influenza-Like Illness: A Cost-Consequence Analysis for High-Risk Patients in Primary Care in Germany.Advances in therapy · 2025Article
- Battling Influenza in Elderly Patients: A Case of Severe Influenza A With Complications in a High-Risk Patient.Cureus · 2025Article
- Comparative Evaluation of Risk of Death in Mechanically Ventilated Patients With COVID-19 and Influenza: A Population-Based Cohort Study.Journal of clinical medicine research · 2025Article
- Class-acquired influenza is more severe than non-class-acquired influenza: a survey for multi-school teachers.Frontiers in public health · 2025Article
- Laboratory-Confirmed Influenza-Associated Hospitalizations Among Children and Adults - Influenza Hospitalization Surveillance Network, United States, 2010-2023.Morbidity and mortality weekly report. Surveillance summaries (Washington, D.C. : 2002) · 2024Article
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Abstract
backgroundPneumonia is common in adults hospitalized with laboratory-confirmed influenza, but the association between timeliness of influenza antiviral treatment and severe clinical outcomes in patients with influenza-associated pneumonia is not well characterized.
methodsWe included adults aged ≥18 years hospitalized with laboratory-confirmed influenza and a discharge diagnosis of pneumonia over 7 influenza seasons (2012-2019) sampled from a multistate population-based surveillance network. We evaluated 3 treatment groups based on timing of influenza antiviral initiation relative to admission date (day 0, day 1, days 2-5). Baseline characteristics and clinical outcomes were compared across groups using unweighted counts and weighted percentages accounting for the complex survey design. Logistic regression models were generated to evaluate the association between delayed treatment and 30-day all-cause mortality.
resultsA total of 26 233 adults were sampled in the analysis. Median age was 71 years and most (92.2%) had ≥1 non-immunocompromising condition. Overall, 60.9% started antiviral treatment on day 0, 29.5% on day 1, and 9.7% on days 2-5 (median, 2 days). Baseline characteristics were similar across groups. Thirty-day mortality occurred in 7.5%, 8.5%, and 10.2% of patients who started treatment on day 0, day 1, and days 2-5, respectively. Compared to those treated on day 0, adjusted odds ratio for death was 1.14 (95% confidence interval [CI], 1.01-1.27) in those starting treatment on day 1 and 1.40 (95% CI, 1.17-1.66) in those starting on days 2-5.
conclusionsDelayed initiation of antiviral treatment in patients hospitalized with influenza-associated pneumonia was associated with higher risk of death, highlighting the importance of timely initiation of antiviral treatment at admission.
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