Evidence map›Paper›PMID 39172734›Full record

ArticleJournal of the American Chemical Society2024

C3 Selective Hydroxylation of Pyridines via Photochemical Valence Isomerization of Pyridine

Chen-Yan Cai, Si-Jie Chen, Rohan R Merchant, Yuzuru Kanda, Tian Qin

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Photoisomerization of Isatogens to Benzoxazin-4-ones.The Journal of organic chemistry · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. An Oxygen Walk Approach for C3 Selective Hydroxylation of Pyridines.Synlett : accounts and rapid communications in synthetic organic chemistry · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chen-Yan CaiDepartment of Biochemistry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390, United States.
Si-Jie ChenDepartment of Discovery Chemistry, Merck & Co., Inc., South San Francisco, California 94080, United States.ORCID 0000-0001-9836-6892
Rohan R MerchantDepartment of Discovery Chemistry, Merck & Co., Inc., South San Francisco, California 94080, United States.ORCID 0000-0002-5472-8780
Yuzuru KandaNovartis Biomedical Research, Cambridge, Massachusetts 02139, United States.
Tian QinDepartment of Biochemistry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390, United States.ORCID 0000-0001-7225-3224

Funding

Development of Sulfur-Based Reactions with Translational ApplicationsR01GM141088 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Tian Qin · 2021 to 2026
$2.1M
NIGMS NIH HHS R01 GM141088
6 · The paper itself

Abstract

The C-H hydroxylation of the pyridine C3 position is a highly desirable transformation but remains a great challenge due to the inherent electronic properties of this heterocycle core which bring difficulties in chemical reactivity and regioselectivity. Herein we present an efficient method for formal C3 selective hydroxylation of pyridines via photochemical valence isomerization of pyridine

Identifiers

PMID39172734
PMCPMC11822719

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.