Evidence map›Paper›PMID 39172544›Full record

ArticleGigaScience2024

TooManyCellsInteractive: A visualization tool for dynamic exploration of single-cell data.

Conor Klamann, Christie J Lau, Javier Ruiz-Ramírez, Gregory W Schwartz

Abstract read
In one paragraph

Article in GigaScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Conor KlamannData Sciences Institute, University of Toronto, Toronto, ON M5G 1Z5, Canada.ORCID 0009-0003-3597-8738
Christie J LauPrincess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada.ORCID 0000-0003-4008-386X
Javier Ruiz-RamírezPrincess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada.ORCID 0000-0002-6581-3286
Gregory W SchwartzPrincess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada.ORCID 0000-0003-4003-3045

Funding

Natural Sciences and Engineering Research Council of Canada RGPIN-2023-04713Social Sciences and Humanities Research Council of Canada NFRFE-2022-00681
6 · The paper itself

Abstract

backgroundAs single-cell sequencing technologies continue to advance, the growing volume and complexity of the ensuing data present new analytical challenges. Large cellular populations from single-cell atlases are more difficult to visualize and require extensive processing to identify biologically relevant subpopulations. Managing these workflows is also laborious for technical users and unintuitive for nontechnical users.

resultsWe present TooManyCellsInteractive (TMCI), a browser-based JavaScript application for interactive exploration of cell populations. TMCI provides an intuitive interface to visualize and manipulate a radial tree representation of hierarchical cell subpopulations and allows users to easily overlay, filter, and compare biological features at multiple resolutions. Here we describe the software architecture and demonstrate how we used TMCI in a pan-cancer analysis to identify unique survival pathways among drug-tolerant persister cells.

conclusionsTMCI will facilitate exploration and visualization of large-scale sequencing data in a user-friendly way. TMCI is freely available at https://github.com/schwartzlab-methods/too-many-cells-interactive. An example tree from data within this article is available at https://tmci.schwartzlab.ca/.

Indexed as

Single-Cell AnalysisSoftwareComputational BiologyHumansNeoplasmsbig databrowser-basedcell linedata visualizationdrug-tolerant persister cellshierarchical clusteringinteractive graphical user interfacesingle-cell sequencing

Identifiers

PMID39172544
PMCPMC11340645

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.