Evidence map›Paper›PMID 39172355›Full record

ArticleBrain imaging and behavior2024

Brain structural changes in diabetic retinopathy patients: a combined voxel-based morphometry and surface-based morphometry study.

Yaqi Song, Tianye Xu, Xiujuan Chen, Ning Wang, Zhongru Sun, Jinhua Chen, Jianguo Xia, Weizhong Tian

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Article in Brain imaging and behavior, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

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3citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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3 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Yaqi Song *Taizhou School of Clinical Medicine, Nanjing Medical University, Taizhou, Jiangsu, 225300, China.
Tianye XuGraduate School of Dalian Medical University, Dalian, Liaoning, 116044, China.
Xiujuan ChenDepartment of Ophthalmology, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, Jiangsu, 225300, China.
Ning WangDepartment of Medical Imaging, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, Jiangsu, 225300, China.
Zhongru SunDepartment of Medical Imaging, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, Jiangsu, 225300, China.
Jinhua ChenDepartment of Medical Imaging, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, Jiangsu, 225300, China.
Jianguo XiaDepartment of Medical Imaging, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, Jiangsu, 225300, China. xiajianguo@njmu.edu.cn.
Weizhong TianDepartment of Medical Imaging, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, Jiangsu, 225300, China. Tianjstztwz@163.com.

Funding

Six Talent Peaks Project in Jiangsu Province 2015-WSN-119The fifth phase of the "333 Project" funded scientific research project of Jiangsu Province BRA2017175the Scientific research project of Jiangsu Provincial Health Care Commission H2018093
6 · The paper itself

Abstract

The aim of this study was to investigate alterations in gray matter structure among individuals diagnosed with diabetic retinopathy (DR). This study included a cohort of 32 diabetic patients with retinopathy (DR group, n = 32) and 38 healthy adults (HC group, n = 38). Both cohorts underwent comprehensive psychological and cognitive assessments alongside structural magnetic resonance imaging. The brain's gray matter volume and morphology were analyzed using voxel-based morphometry (VBM) and surface-based morphometry (SBM). Partial correlation analysis was employed to investigate the associations between differences in gray matter volume (GMV) across diverse brain regions and the outcomes of cognitive psychological tests as well as clinical indicators. The VBM results revealed that, in comparison to the healthy control (HC) group, patients with diabetic retinopathy (DR) exhibited reduced gray matter volume (GMV) in the right fusiform gyrus, inferior frontal gyrus, opercular part, and left hippocampus; conversely, an increase in GMV was observed in the right thalamus. The SBM results indicated cortical thinning in the left caudal anterior cingulate cortex, left superior frontal gyrus, left parahippocampal gyrus, and bilateral lingual gyrus in the DR group. Sulcal depth (SD) exhibited increased values in the bilateral rostral middle frontal gyrus, superior frontal gyrus, frontal pole, left precentral gyrus, postcentral gyrus, lateral orbitofrontal gyrus, and right paracentral gyrus. Local gyrification indices (LGIs) decreased in the left caudal middle frontal gyrus and superior frontal gyrus. The fractal dimension (FD) decreased in the posterior cingulate gyrus and isthmus of the cingulate gyrus. The left hippocampal gray matter volume (GMV) in patients with diabetic retinopathy was negatively correlated with disease duration (r = -0.478, p = 0.008) and self-rating depression scale (SAS) score (r = -0.381, p = 0.038). The structural alterations in specific brain regions of individuals with DR, which may contribute to impairments in cognition, emotion, and behavior, provide valuable insights into the neurobiological basis underlying these dysfunctions.

Indexed as

BrainDiabetic RetinopathyGray MatterMagnetic Resonance ImagingAdultFemaleHumansImage Processing, Computer-AssistedMaleMiddle AgedNeuropsychological TestsOrgan SizeDiabetic retinopathyStructural magnetic resonance ImagingSurface-based morphometryType 2 diabetesVoxel-based morphometry

Identifiers

PMID39172355

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