Evidence map›Paper›PMID 39172295›Full record

ReviewCurrent cardiology reports2024

Lymphatic System Development and Function.

Harish P Janardhan, Brianna T Wachter, Chinmay M Trivedi

Abstract readReview
In one paragraph

Review in Current cardiology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Harish P Janardhan *Division of Cardiovascular Medicine, UMass Chan Medical School, Worcester, MA, 01605, USA.
Brianna T Wachter *Division of Cardiovascular Medicine, UMass Chan Medical School, Worcester, MA, 01605, USA.
Chinmay M TrivediDivision of Cardiovascular Medicine, UMass Chan Medical School, Worcester, MA, 01605, USA. chinmay.trivedi@umassmed.edu.

Funding

Epigenetic regulation of lymphatic developmentR01HL141377 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI TRIVEDI, CHINMAY M · 2018 to 2025
$4.1M
NHLBI NIH HHS R01 HL141377
6 · The paper itself

Abstract

purpose of reviewThis review delves into recent advancements in understanding generalized and organ-specific lymphatic development. It emphasizes the distinct characteristics and critical anomalies that can impair lymphatic function. By exploring developmental mechanisms, the review seeks to illuminate the profound impact of lymphatic malformations on overall health and disease progression. RECENT

findingsThe introduction of genome sequencing, single-cell transcriptomic analysis, and advanced imaging technologies has significantly enhanced our ability to identify and characterize developmental defects within the lymphatic system. As a result, a wide range of lymphatic anomalies have been uncovered, spanning from congenital abnormalities present at birth to conditions that can become life-threatening in adulthood. Additionally, recent research highlights the heterogeneity of lymphatics, revealing organ-specific developmental pathways, unique molecular markers, and specialized physiological functions specific to each organ. A deeper understanding of the unique characteristics of lymphatic cell populations in an organ-specific context is essential for guiding future research into lymphatic disease processes. An integrated approach to translational research could revolutionize personalized medicine, where treatments are precisely tailored to individual lymphatic profiles, enhancing effectiveness and minimizing side effects.

Indexed as

Lymphatic SystemHumansLymphangiogenesisLymphatic AbnormalitiesLymphatic VesselsLymphatic developmentLymphatic malformationOrgan-specific lymphatic function

Identifiers

PMID39172295
PMCPMC12143451

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.