Evidence map›Paper›PMID 39172292›Full record

ArticleClinical rheumatology2024

The natural history of marginal erosions in hands with and without osteoarthritis.

Hari A Sharma, Timothy E McAlindon, Mary B Roberts, Ida K Haugen, Grace H Lo, Jeffrey Duryea, Lena F Schaefer, Stacy E Smith, Charles B Eaton, Jeffrey B Driban

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PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical rheumatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hari A SharmaUMass Chan Medical School, Worcester, MA, USA.ORCID http://orcid.org/0000-0002-8641-1702
Timothy E McAlindonDivision of Rheumatology, Allergy, and Immunology, Tufts Medical Center, Boston, MA, USA.
Mary B RobertsCenter for Primary Care and Prevention, Kent Hospital, Pawtucket, RI, USA.
Ida K HaugenCenter for Treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Diakonhjemmet Hospital, Oslo, Norway.
Grace H LoDepartment of Medicine, Baylor College of Medicine, Houston, TX, USA.
Jeffrey DuryeaDepartment of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Lena F SchaeferDepartment of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Stacy E SmithDepartment of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Charles B EatonCenter for Primary Care and Prevention, Kent Hospital, Pawtucket, RI, USA.
Jeffrey B DribanDepartment of Population and Quantitative Health Sciences, UMass Chan Medical School, Worcester, MA, USA. jeffrey.driban@umassmed.edu.ORCID http://orcid.org/0000-0001-6098-4273

Funding

Constitutional and metabolic factors associated with the development of Hand OAR01AR066378 · NIAMS · TUFTS MEDICAL CENTER · PI MCALINDON, TIMOTHY E · 2015 to 2018
$2.6M
DATA COORDINATING CENTER FOR THE OSTEOARTHRITIS INITIATIVE-264022258N01AR022258 · NIAMS · UNIVERSITY OF CALIFORNIA SYS OFFICE/PRES · 2003 to 2003
–
CLINICAL CENTERS FOR THE OSTEOARTHRITIS INITIATIVE-264022259-264022259N01AR022259 · NIAMS · UNIVERSITY OF MARYLAND AT BALT · PI HOCHBERG, MARC C. · 2002 to 2006
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CLINICAL CENTERS FOR THE OSTEOARTHRITIS INITIATIVE-N01AR22260N01AR022260 · NIAMS · UNIVERSITY OF PITTSBURGH · PI KWOH, KENT · 2002 to 2006
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CLINICAL CENTERS FOR THE OSTEOARTHRITIS INITIATIVE-N01AR22261N01AR022261 · NIAMS · OHIO STATE UNIVERSITY RESEARCH · PI JACKSON, REBECCA · 2002 to 2006
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CLINICAL CENTER FOR THE OSTEOARTHRITIS-264022262-264022262N01AR022262 · NIAMS · THE MEMORIAL HOSPITAL · PI ASSAF, ANNLOUISE R. · 2002 to 2006
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NIAMS NIH HHS R01 AR066378NIH HHS N01-AR-2-2258NIH HHS N01-AR-2-2259NIH HHS N01-AR-2-2260NIH HHS N01-AR-2-2261NIH HHS N01-AR-2-2262
6 · The paper itself

Abstract

INTRODUCTION/

objectivesAmong people with or without hand osteoarthritis, we aimed to identify characteristics of people (e.g., age and gender) with marginal erosions (MEs). We also examined changes in MEs during 48 months. We described radiographic severity and progression among joints with MEs, changes in MEs, or central erosions (CEs).

designWe studied participants from the Osteoarthritis Initiative with baseline and 48-month hand radiographs. A radiologist and rheumatologist evaluated the radiographs for disease severity (Kellgren-Lawrence grades) and erosions (central or marginal), respectively. We used descriptive statistics to characterize participants and calculated frequencies at the joint level.

resultsOf the 3558 participants, 89 had a ME at baseline. People with MEs were more often male, older, and ever (former and current) smokers than those without a ME. There was no difference in inflammatory biomarkers or the presence of hand pain between individuals with and without a baseline ME. Almost all hands had only one ME (80%), whereas only 50% of individuals with CEs had only one CE at baseline. Compared to CEs, MEs appeared more frequently in joints without osteoarthritis (54% vs. < 1%). Approximately 18% of joints with an ME progressed in Kellgren-Lawrence grade versus 4% without ME. Among the joints with an ME at baseline, 10% resolved by 48 months. Less than 0.1% of joints developed a new ME.

conclusionMEs appear to be distinct from CEs. MEs are predominantly present in males, isolated to one specific joint without osteoarthritis within a hand, and possibly predictive of radiographic progression. Key Points • Marginal erosions appear to be distinct from central erosions. • Most marginal erosions occur in joints without radiographic osteoarthritis. • Radiographic progression but not hand pain is more common in joints with a marginal erosion than without one.

Indexed as

Disease ProgressionHand JointsOsteoarthritisRadiographySeverity of Illness IndexAgedFemaleHandHumansMaleMiddle AgedCentral erosionsErosive hand osteoarthritisMarginal erosionsRadiographic features

Identifiers

PMID39172292
PMCPMC12010253

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.