Evidence map›Paper›PMID 39172165›Full record

ArticleNeuroradiology2024

Iron changes within infarct tissue in ischemic stroke patients after successful reperfusion quantified using QSM.

Victoria Mercy Kataike, Patricia M Desmond, Christopher Steward, Peter J Mitchell, Christian Davey, Nawaf Yassi, Andrew Bivard, Mark W Parsons, Bruce C V Campbell, Felix Ng and 1 more

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Article in Neuroradiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Victoria Mercy KataikeDepartment of Radiology, The University of Melbourne, Parkville, VIC, 3050, Australia. mkataike@student.unimelb.edu.au.ORCID http://orcid.org/0000-0002-8462-7761
Patricia M DesmondDepartment of Radiology, The University of Melbourne, Parkville, VIC, 3050, Australia.ORCID http://orcid.org/0000-0002-4803-6323
Christopher StewardDepartment of Radiology, The University of Melbourne, Parkville, VIC, 3050, Australia.ORCID http://orcid.org/0000-0001-8949-4139
Peter J MitchellDepartment of Radiology, The University of Melbourne, Parkville, VIC, 3050, Australia.ORCID http://orcid.org/0000-0002-8337-7529
Christian DaveyStatistical Consulting Centre, School of Mathematics and Statistics, The University of Melbourne, Parkville, VIC, Australia.ORCID http://orcid.org/0000-0003-3097-9769
Nawaf YassiDepartment of Medicine, The Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia.ORCID http://orcid.org/0000-0002-0685-0060
Andrew BivardDepartment of Medicine, The Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia.ORCID http://orcid.org/0000-0001-7762-5832
Mark W ParsonsHunter Medical Research Institute, Newcastle, New South Wales, Australia.ORCID http://orcid.org/0000-0001-8874-2487
Bruce C V CampbellDepartment of Medicine, The Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia.ORCID http://orcid.org/0000-0003-3632-9433
Felix NgDepartment of Medicine, The Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia.ORCID http://orcid.org/0000-0001-6973-8677
Vijay VenkatramanDepartment of Radiology, The University of Melbourne, Parkville, VIC, 3050, Australia.ORCID http://orcid.org/0000-0002-8706-5936

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeFor nearly half of patients who undergo Endovascular Thrombectomy following ischemic stroke, successful recanalisation does not guarantee a good outcome. Understanding the underlying tissue changes in the infarct tissue with the help of biomarkers specific to ischemic stroke could offer valuable insights for better treatment and patient management decisions. Using quantitative susceptibility mapping (QSM) MRI to measure cerebral iron concentration, this study aims to track the progression of iron within the infarct lesion after successful reperfusion.

methodsIn a prospective study of 87 ischemic stroke patients, successfully reperfused patients underwent MRI scans at 24-to-72 h and 3 months after reperfusion. QSM maps were generated from gradient-echo MRI images. QSM values, measured in parts per billion (ppb), were extracted from ROIs defining the infarct and mirror homolog in the contralateral hemisphere and were compared cross-sectionally and longitudinally.

resultsQSM values in the infarct ROIs matched those of the contralateral ROIs at 24-to-72 h, expressed as median (interquartile range) ppb [0.71(-7.67-10.09) vs. 2.20(-10.50-14.05) ppb, p = 0.55], but were higher at 3 months [10.68(-2.30-21.10) vs. -1.27(-12.98-9.82) ppb, p < 0.001]. The infarct QSM values at 3 months were significantly higher than those at 24-to-72 h [10.41(-2.50-18.27) ppb vs. 1.68(-10.36-12.25) ppb, p < 0.001]. Infarct QSM at 24-to-72 h and patient outcome measured at three months did not demonstrate a significant association.

conclusionFollowing successful endovascular reperfusion, iron concentration in infarct tissue, as measured by QSM increases over time compared to that in healthy tissue. However, its significance warrants further investigation.

Indexed as

IronIschemic StrokeMagnetic Resonance ImagingAgedFemaleHumansMaleMiddle AgedProspective StudiesReperfusionTreatment OutcomeIronInfarct tissueIronIschemic strokeQuantitative susceptibility mappingSuccessful reperfusion

Identifiers

PMID39172165
PMCPMC11611990

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.