Evidence map›Paper›PMID 39172101›Full record

ArticleAging2024

LncRNA HAGLR regulates gastric cancer progression by regulating the miR-20a-5p/E2F1 axis.

Qingwei Liu, Yong Li, Bibo Tan, Qun Zhao, Liqiao Fan, Zhidong Zhang, Dong Wang, Xuefeng Zhao, Yu Liu, Wenbo Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Qingwei LiuThe Third Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Yong LiThe Third Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Bibo TanThe Third Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Qun ZhaoThe Third Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Liqiao FanThe Third Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Zhidong ZhangThe Third Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Dong WangThe Third Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Xuefeng ZhaoThe Third Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Yu LiuThe Third Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Wenbo LiuThe Third Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGastric cancer (GC) stands as a prevalent and challenging malignancy within the gastrointestinal tract. The potential of long non-coding RNAs (lncRNAs) as biomarkers and therapeutic targets in oncology has garnered immense research interest. This study aims to elucidate the relevance, biological roles, and mechanistic pathways of LncRNA HAGLR in the context of GC.

methodsThe assessments of cell proliferation, migration, and invasion were executed using CCK-8, wound healing, and Transwell assays. The interactions between HAGLR, miR-20a-5p, and E2F1 were appraised through luciferase reporter assays, fluorescence

resultsElevated levels of HAGLR in GC cells and tissue specimens were linked to worse patient outcomes. The inhibition of HAGLR led to a decrease in GC cell proliferation, migration, and invasion, whereas its activation prompted contrary effects. The impact of HAGLR on cell migration and invasion was notably associated with epithelial-mesenchymal transition (EMT). Through bioinformatics, luciferase reporter assays, FISH, RIP, and Western blot analyses, it was revealed that HAGLR acts as a molecular sponge for miR-20a-5p, consequently augmenting E2F1 levels.

conclusionsThe data suggest that the HAGLR/miR-20a-5p/E2F1 regulatory cascade is implicated in GC pathogenesis, offering a novel therapeutic avenue for GC management.

Indexed as

Cell MovementCell ProliferationE2F1 Transcription FactorGene Expression Regulation, NeoplasticMicroRNAsRNA, Long NoncodingStomach NeoplasmsAnimalsCell Line, TumorDisease ProgressionEpithelial-Mesenchymal TransitionFemaleHumansMaleMiceMice, NudeE2F1 protein, humanE2F1 Transcription FactorMicroRNAsMIRN20a microRNA, humanRNA, Long NoncodingE2F1gastric cancerlncRNA HAGLRmiR-20a-5p

Identifiers

PMID39172101
PMCPMC11386921

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.