ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2025
Serum ferritin measurements differ according to the assay used: implications for iron therapy in restless legs syndrome.
Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Bringing iron to the brain for restless legs.Sleep · 2025Article
- Erratum to: Serum ferritin measurements differ according to the assay used: implications for iron therapy in restless legs syndromeJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Article
- Low iron status and cognitive impairment in northern China community-dwelling older adults: a cross-sectional study.Frontiers in nutrition · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesSerum ferritin levels are used to determine the need for iron supplementation in patients with restless legs syndrome. The purpose of this study was to determine whether immunoassay measurement of serum ferritin yields varying levels according to different manufacturers' assays, with resultant variation in cutoff values.
methodsWe compared serum ferritin levels using 116 clinical samples assessed by the Beckman and Roche methods.
resultsAlthough there was a high correlation between results obtained from the 2 methods (R
conclusionsIt is uncertain which assays were used to measure serum ferritin in the seminal studies on which current guidelines for iron therapy for restless legs syndrome are based. In view of this uncertainty, as well as the limited data on which current recommendations are based, clinicians should be flexible in using recommended serum ferritin cutoff values, also using percentage of transferrin saturation. Assuming that Beckman or equivalent assays were used, centers using the Roche method need to adjust the cutoffs for administration of oral iron and intravenous iron recommended by current practice guidelines to avoid withholding treatment for restless legs syndrome patients who might benefit from iron supplementation. CITATION: Silber MH, Block DR, St. Louis EK. Serum ferritin measurements differ according to the assay used: implications for iron therapy in restless legs syndrome.
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