Evidence map›Paper›PMID 39172025›Full record

ReviewImmunoHorizons2024

From Womb to World: Exploring the Immunological Connections between Mother and Child.

Bobby J Cherayil, Nitya Jain

Abstract readReview
In one paragraph

Review in ImmunoHorizons, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Impact of Gestational Maternal SARS-CoV-2 Infection on Neonatal Inflammatory Biomarkers.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Bobby J CherayilMucosal Immunology and Biology Research Center, Mass General for Children, Charlestown, MA.ORCID 0000-0002-6602-3374
Nitya JainMucosal Immunology and Biology Research Center, Mass General for Children, Charlestown, MA.

Funding

Maternal Microbial Influences on Early-life Thymic T cell developmentR01AI154626 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI JAIN, NITYA · 2020 to 2022
$1.5M
Regulation of early life immunity by maternal microchimeric cellsR21AI168518 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI JAIN, NITYA · 2022 to 2023
$455k
NIAID NIH HHS R01 AI154626NIAID NIH HHS R21 AI168518
6 · The paper itself

Abstract

Mother and child are immunologically interconnected by mechanisms that we are only beginning to understand. During pregnancy, multiple molecular and cellular factors of maternal origin are transferred across the placenta and influence the development and function of the fetal and newborn immune system. Altered maternal immune states arising from pregnancy-associated infections or immunizations have the potential to program offspring immune function in ways that may have long-term health consequences. In this study, we review current literature on the impact of prenatal infection and vaccination on the developing immune system, highlight knowledge gaps, and look to the horizon to envision maternal interventions that could benefit both the mother and her child.

Indexed as

VaccinationChildFemaleFetusHumansImmune SystemInfant, NewbornMaternal-Fetal ExchangeMothersPlacentaPregnancyPregnancy Complications, InfectiousPrenatal Exposure Delayed Effects

Identifiers

PMID39172025
PMCPMC11374749

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.