ArticleJournal of integrative plant biology2024
The OsAGO2-OsNAC300-OsNAP module regulates leaf senescence in rice.
Article in Journal of integrative plant biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Transposable element-driven expansion of enhancer RNA repertoires underlies regulatory innovation and polyploid adaptation in cereal crops.Plant communications · 2026Article
- Identification and Fine Mapping ofBiology · 2026Article
- The C2H2-type zinc finger protein ZOS202 regulates leaf senescence in rice by targeting senescence-associated transcription factors and ROS homoeostasis.The Plant journal : for cell and molecular biology · 2026Article
- Molecular and Physiological Regulation of Premature Leaf Senescence in Rice.Plants (Basel, Switzerland) · 2026Review
- Heat Shock Transcription Factor OsHsfc1a Enhances Rice Seedling Thermotolerance by Regulating OsMFT1 and Preserving Chloroplast Structure Under Heat Stress.Plant biotechnology journal · 2026Article
- Genetic and transcriptomic identification of WPG1 controlling nitrogen allocation-related leaf chlorisis and premature senescence in wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- A 24-nt miR9560 modulates the transporter gene BrpHMA2 expression in Brassica parachinensis.The plant genome · 2025Article
- The OsAGO2-OsNAC300-OsNAP module regulates leaf senescence in rice.Journal of integrative plant biology · 2024Article
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10 authors.
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Abstract
Leaves play a crucial role in the growth and development of rice (Oryza sativa) as sites for the production of photosynthesis. Early leaf senescence leads to substantial drops in rice yields. Whether and how DNA methylation regulates gene expression and affects leaf senescence remains elusive. Here, we demonstrate that mutations in rice ARGONAUTE 2 (OsAGO2) lead to premature leaf senescence, with chloroplasts in Osago2 having lower chlorophyll content and an abnormal thylakoid structure compared with those from wild-type plants. We show that OsAGO2 associates with a 24-nt microRNA and binds to the promoter region of OsNAC300, which causes DNA methylation and suppressed expression of OsNAC300. Overexpressing OsNAC300 causes the similar premature leaf senescence as Osago2 mutants and knocking out OsNAC300 in the Osago2 mutant background suppresses the early senescence of Osago2 mutants. Based on yeast one-hybrid, dual-luciferase, and electrophoresis mobility shift assays, we propose that OsNAC300 directly regulates transcription of the key rice aging gene NAC-like, activated by APETALA3/PISTILLATA (OsNAP) to control leaf senescence. Our results unravel a previously unknown epigenetic regulatory mechanism underlying leaf senescence in which OsAGO2-OsNAC300-OsNAP acts as a key regulatory module of leaf senescence to maintain leaf function.
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