Evidence map›Paper›PMID 39171752›Full record

ReviewAmerican journal of physiology. Endocrinology and metabolism2024

Key questions and gaps in understanding adipose tissue macrophages and early-life metabolic programming.

Kaitlyn B Hill, Gregory P Mullen, Prabhakara R Nagareddy, Kurt A Zimmerman, Michael C Rudolph

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in American journal of physiology. Endocrinology and metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kaitlyn B HillDepartment of Biochemistry and Physiology, Harold Hamm Diabetes Center, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States.ORCID 0000-0002-7805-5197
Gregory P MullenDepartment of Biochemistry and Physiology, Harold Hamm Diabetes Center, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States.
Prabhakara R NagareddyDepartment of Internal Medicine, Cardiovascular Section, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States.
Kurt A ZimmermanDepartment of Internal Medicine, Division of Nephrology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States.ORCID 0000-0003-1798-8046
Michael C RudolphDepartment of Biochemistry and Physiology, Harold Hamm Diabetes Center, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States.ORCID 0000-0002-6147-212X

Funding

Thrombocytopoiesis in Diabetes: Role of Damage Associated Molecular PatternsR01HL137799 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI NAGAREDDY, PRABHAKARA REDDY · 2018 to 2022
$3.2M
A dialogue between neutrophils and monocytes for effective resolution of inflammation following acute myocardial injuryR01HL156856 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Prabhakara Reddy Nagareddy · 2022 to 2026
$2.9M
Targeting kidney resident macrophage niche filling to slow cystic kidney diseaseR01DK129255 · NIDDK · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Kurt A Zimmerman · 2022 to 2026
$1.6M
Investigating CD4 T regulatory cells during rapid cystogenesisK01DK119375 · NIDDK · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI ZIMMERMAN, KURT A · 2020 to 2023
$608k
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) NIH R01HL137799HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) NIH R01HL156856HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) NIH K01DK119375-01A1HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) NIH R01DK129255NHLBI NIH HHS R01 HL137799NHLBI NIH HHS R01 HL156856NIDDK NIH HHS K01 DK119375NIDDK NIH HHS R01 DK129255Oklahoma Center for Adult Stem Cell Research (OCASCR)Presbyterian Health Foundation (PHF)
6 · The paper itself

Abstract

The global obesity epidemic, with its associated comorbidities and increased risk of early mortality, underscores the urgent need for enhancing our understanding of the origins of this complex disease. It is increasingly clear that metabolism is programmed early in life and that metabolic programming can have life-long health consequences. As a critical metabolic organ sensitive to early-life stimuli, proper development of adipose tissue (AT) is crucial for life-long energy homeostasis. Early-life nutrients, especially fatty acids (FAs), significantly influence the programming of AT and shape its function and metabolism. Of growing interest are the dynamic responses during pre- and postnatal development to proinflammatory omega-6 (

Indexed as

Adipose TissueMacrophagesAnimalsFemaleHumansMetabolic ReprogrammingObesityPregnancyPrenatal Exposure Delayed Effectsadipose tissue macrophageearly-life metabolic programmingobesityomega-3 fatty acidomega-6 fatty acid

Identifiers

PMID39171752
PMCPMC11482221

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.