Evidence map›Paper›PMID 39171589›Full record

SynthesisCurrent pharmaceutical design2024

Effects of

Yoon-A Park, Juyeong Park, Jeong Yee, Hye Sun Gwak

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Current pharmaceutical design, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yoon-A ParkCollege of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, 03760, Republic of Korea.ORCID 0000-0002-9162-2555
Juyeong ParkCollege of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, 03760, Republic of Korea.
Jeong YeeSchool of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi-do, 16419, South Korea.ORCID 0000-0001-8439-143X
Hye Sun GwakCollege of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, 03760, Republic of Korea.ORCID 0000-0003-0278-2563

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSirolimus, one of the immunosuppressive drugs administered to renal transplant recipients, is metabolized by cytochrome P450 (CYP) 3A5. Accordingly,

methodsWe searched for studies published up to 13 June 2024 from PubMed, Embase, Cochrane Library, and Web of Science. We reviewed studies on the relationship between

resultsA total of seven studies were included. The weight-adjusted C0 /D ratio of sirolimus was significantly higher in patients with the

conclusionOur meta-analysis showed a significant effect for the

Indexed as

Cytochrome P-450 CYP3AImmunosuppressive AgentsKidney TransplantationPolymorphism, GeneticSirolimusBody WeightHumansCYP3A5 protein, humanCytochrome P-450 CYP3AImmunosuppressive AgentsSirolimusCytochrome P450 3A5pharmacogenomicspharmacokineticspolymorphism.renal transplantationsirolimus

Identifiers

PMID39171589

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.