Evidence map›Paper›PMID 39171403›Full record

ArticleCirculation. Cardiovascular quality and outcomes2024

Empowering Research With the American Heart Association Get With The Guidelines Registries Through Integration of a Database and Research Tools.

Chandler Beon, Lanjing Wang, Vihaan Manchanda, Pratheek Mallya, Haoyun Hong, Holly Picotte, Kathie Thomas, Jennifer L Hall, Juan Zhao, Xue Feng

Abstract read
In one paragraph

Article in Circulation. Cardiovascular quality and outcomes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chandler BeonData Science and Evaluation, American Heart Association, Dallas, TX (C.B., L.W., V.M., P.M., H.H., H.P., K.T., J.L.H., J.Z., X.F.).ORCID 0000-0001-6868-0370
Lanjing WangData Science and Evaluation, American Heart Association, Dallas, TX (C.B., L.W., V.M., P.M., H.H., H.P., K.T., J.L.H., J.Z., X.F.).ORCID 0009-0004-3422-8238
Vihaan ManchandaData Science and Evaluation, American Heart Association, Dallas, TX (C.B., L.W., V.M., P.M., H.H., H.P., K.T., J.L.H., J.Z., X.F.).
Pratheek MallyaData Science and Evaluation, American Heart Association, Dallas, TX (C.B., L.W., V.M., P.M., H.H., H.P., K.T., J.L.H., J.Z., X.F.).ORCID 0000-0001-5545-2256
Haoyun HongData Science and Evaluation, American Heart Association, Dallas, TX (C.B., L.W., V.M., P.M., H.H., H.P., K.T., J.L.H., J.Z., X.F.).ORCID 0009-0005-8858-4833
Holly PicotteData Science and Evaluation, American Heart Association, Dallas, TX (C.B., L.W., V.M., P.M., H.H., H.P., K.T., J.L.H., J.Z., X.F.).ORCID 0009-0004-0095-897X
Kathie ThomasData Science and Evaluation, American Heart Association, Dallas, TX (C.B., L.W., V.M., P.M., H.H., H.P., K.T., J.L.H., J.Z., X.F.).ORCID 0009-0006-1692-3282
Jennifer L HallData Science and Evaluation, American Heart Association, Dallas, TX (C.B., L.W., V.M., P.M., H.H., H.P., K.T., J.L.H., J.Z., X.F.).ORCID 0000-0002-5103-5399
Juan ZhaoData Science and Evaluation, American Heart Association, Dallas, TX (C.B., L.W., V.M., P.M., H.H., H.P., K.T., J.L.H., J.Z., X.F.).ORCID 0000-0003-1429-0662
Xue FengData Science and Evaluation, American Heart Association, Dallas, TX (C.B., L.W., V.M., P.M., H.H., H.P., K.T., J.L.H., J.Z., X.F.).ORCID 0000-0002-2181-9889

Funding

Data HarmonizationR61NS120246 · NINDS · DUKE UNIVERSITY · PI PENCINA, MICHAEL J · 2020 to 2022
$2.0M
Data HarmonizationR33NS120246 · NINDS · DUKE UNIVERSITY · PI PENCINA, MICHAEL J · 2023 to 2024
$1.3M
NINDS NIH HHS R33 NS120246NINDS NIH HHS R61 NS120246
6 · The paper itself

Abstract

backgroundThe American Heart Association's Get With The Guidelines (GWTG) has emerged as a vital resource in advancing the standards and practices of inpatient care across stroke, heart failure, coronary artery disease, atrial fibrillation, and resuscitation focus areas. The GWTG registry data have also created new opportunities for secondary use of real-world clinical data in biomedical research. Our goal was to implement a scalable database with an integrated user interface (UI) to improve GWTG data management and accessibility.

methodsThe curation of registry data begins by going through a data processing and quality control pipeline programmed in Python. This pipeline includes data cleaning and record exclusion, variable derivation and unit harmonization, limited data set preparation, and documentation generation of the registry data. The database was built using PostgreSQL, and integrations between the database and the UI were built using the Django Web Framework in Python. Smaller subsets of data were created using SQLite database files for distribution purposes. Use cases of these tools are provided in the article.

resultsWe implemented an automated data curation pipeline, centralized database, and UI application for the American Heart Association GWTG registry data. The database and the UI are accessible through a Precision Medicine Platform workspace. As of March 2024, the database contains over 13.2 million cleaned GWTG patient records. The SQLite subsets benefit researchers by optimizing data extraction and manipulation using Structured Query Language. The UI improves accessibility for nontechnical researchers by presenting data in a user-friendly tabular format with intuitive filtering options.

conclusionsWith the implementation of the GWTG database and UI application, we addressed data management and accessibility concerns despite its growing scale. We have launched tools to provide streamlined access and accessibility of GWTG registry data to all researchers, regardless of familiarity or experience in coding.

Indexed as

American Heart AssociationDatabases, FactualPractice Guidelines as TopicRegistriesAccess to InformationBiomedical ResearchCardiovascular DiseasesData CurationData MiningGuideline AdherenceHealth Information InteroperabilityHumansQuality Indicators, Health CareUnited StatesUser-Computer Interfacecardiovascular diseasesdatabaseheart failureregistriesstroke

Identifiers

PMID39171403
PMCPMC12863432

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.